| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AAM-B |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human METTL7A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于METTL7A抗体的模拟参考文献示例(基于领域内常见研究方向构造，非真实文献)：
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1. **文献名称**：*METTL7A as a Novel Prognostic Biomarker in Hepatocellular Carcinoma*
**作者**：Zhang Y, et al.
**摘要**：本研究通过免疫组织化学(使用METTL7A抗体)分析肝癌组织样本，发现METTL7A在肿瘤组织中显著高表达，且与患者预后不良相关。机制研究表明METTL7A可能通过调控脂质代谢途径促进肿瘤进展。
2. **文献名称**：*METTL7A Modulates Lipid Droplet Formation in Adipocytes*
**作者**：Wang L, et al.
**摘要**：利用METTL7A特异性抗体进行Western blot和免疫荧光实验，发现METTL7A缺失导致脂滴形成减少。研究揭示了METTL7A在脂肪细胞分化及脂质储存中的关键作用。
3. **文献名称**：*Structural Insights into METTL7A’s Methyltransferase Activity*
**作者**：Smith J, et al.
**摘要**：通过免疫共沉淀(使用METTL7A抗体)结合质谱分析，鉴定出METTL7A的底物蛋白，并证实其甲基转移酶活性对细胞氧化应激反应具有调控功能。
4. **文献名称**：*METTL7A Expression Correlates with Neurodegenerative Pathology*
**作者**：Chen R, et al.
**摘要**：在小鼠模型和阿尔茨海默病患者脑组织中，采用METTL7A抗体进行免疫组化检测，发现其表达水平与淀粉样斑块沉积呈正相关，提示其可能参与神经退行性病变。
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**注意**：以上文献为示例性内容，实际研究中请通过PubMed、Google Scholar等平台检索真实文献。建议使用关键词“METTL7A antibody”、“METTL7A function”或结合具体研究领域(如癌症、代谢疾病)进行精确查询。
The METTL7A antibody is a tool used to study the methyltransferase-like 7A protein, a member of the methyltransferase superfamily implicated in cellular methylation processes. METTL7A is characterized by a conserved S-adenosylmethionine (SAM)-binding domain, though its specific enzymatic substrates remain under investigation. It is broadly expressed in human tissues, including the liver, kidney, and testes, and localizes to the endoplasmic reticulum. Research links METTL7A to lipid metabolism, cancer progression, and drug resistance, with upregulated expression observed in certain tumors, such as glioblastoma and hepatocellular carcinoma. Its role in lipid droplet regulation and oxidative stress response suggests potential involvement in metabolic disorders and neurodegenerative diseases.
METTL7A antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal regions). They are validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies highlight METTL7A's interaction with proteins involved in lipid biosynthesis and its methylation-dependent regulatory effects on cellular pathways. However, functional ambiguities persist, necessitating further research to clarify its mechanistic contributions to disease. The antibody serves as a critical reagent for exploring METTL7A's biological significance and therapeutic potential.
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