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Rabbit Polyclonal CCDC113 Antibody

  • 中文名: CCDC113抗体
  • 别    名: HSPC065
货号: IPDX09445
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesHSPC065
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CCDC113
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于CCDC113抗体的3篇代表性文献的简要信息(注:以下内容为模拟示例,实际文献需根据具体研究检索):

1. **文献名称**: "Characterization of CCDC113 as a ciliary protein involved in sperm motility regulation"

**作者**: Zhang Y, et al.

**摘要**: 本研究通过生成特异性CCDC113多克隆抗体,发现其在哺乳动物精子鞭毛中高表达。抗体阻断实验表明,CCDC113缺失显著降低精子运动能力,提示其通过调控纤毛轴丝结构影响运动功能。

2. **文献名称**: "CCDC113 antibody-based screening identifies its role in primary ciliary dyskinesia"

**作者**: Smith JL, et al.

**摘要**: 利用自主研发的CCDC113单克隆抗体进行免疫荧光筛查,发现CCDC113在纤毛基体附近定位。临床样本分析显示,携带CCDC113突变的患者纤毛运动异常,抗体检测可作为纤毛运动障碍疾病的辅助诊断工具。

3. **文献名称**: "Development of a novel monoclonal antibody against human CCDC113 for cancer biomarker studies"

**作者**: Tanaka K, et al.

**摘要**: 报道了一种高亲和力抗人CCDC113单克隆抗体的开发,并通过WB和IHC验证其特异性。研究发现CCDC113在肺癌组织中异常高表达,提示其可能作为肿瘤预后标志物,抗体可用于相关病理检测。

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**注意**:以上为模拟文献,实际研究中建议通过PubMed或Google Scholar以“CCDC113 antibody”为关键词检索最新成果。若需具体文献,可提供更详细的研究背景或应用场景。

背景信息

The CCDC113 antibody is a valuable tool for studying the coiled-coil domain-containing protein 113 (CCDC113), a conserved eukaryotic protein implicated in ciliary function and structural organization. CCDC113 localizes to the basal body and axoneme of motile cilia and flagella, playing a role in ciliogenesis and microtubule dynamics. It interacts with components of the intraflagellar transport (IFT) system, crucial for ciliary assembly and signaling. Research links CCDC113 mutations to primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, chronic respiratory infections, and infertility. Antibodies targeting CCDC113 enable the visualization and quantification of the protein in tissues (e.g., respiratory epithelium, sperm flagella) via techniques like immunofluorescence, Western blotting, or immunohistochemistry. These tools also aid in investigating its expression patterns during ciliogenesis, cellular trafficking mechanisms, and functional disruptions in disease models. Recent studies further explore its potential role beyond cilia, including mitosis and DNA repair pathways. The antibody’s specificity and reliability make it essential for elucidating CCDC113’s molecular interactions and pathophysiological contributions, offering insights into therapeutic strategies for cilia-related disorders.

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