| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JM11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CCDC120 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CCDC120抗体的假设性参考文献示例(请注意，以下内容为模拟生成，实际文献可能需要通过数据库进一步验证)：
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1. **标题**: "Characterization of CCDC120 in Mitotic Spindle Regulation"
**作者**: Smith A, et al. (2018)
**摘要**: 本研究利用特异性CCDC120抗体进行免疫沉淀和免疫荧光实验，发现CCDC120蛋白与有丝分裂纺锤体组装相关，敲低后导致染色体分离异常。
2. **标题**: "Development of a Polyclonal Antibody for CCDC120 and Its Application in Cancer Prognosis"
**作者**: Zhang Y, et al. (2020)
**摘要**: 文章报道了一种兔源多克隆CCDC120抗体的开发，并通过IHC证实其在肺癌组织中高表达，且与患者生存率负相关。
3. **标题**: "CCDC120 Localizes to Ciliary Basal Bodies and Regulates Ciliogenesis"
**作者**: Lee JH, et al. (2019)
**摘要**: 通过Western Blot和共聚焦显微技术(使用抗CCDC120抗体)，揭示了CCDC120在纤毛形成中的关键作用，定位在纤毛基体区域。
4. **标题**: "CCDC120 Modulates Cellular Metabolism via mTOR Signaling"
**作者**: Johnson R, et al. (2021)
**摘要**: 研究利用CCDC120抗体进行蛋白质互作分析，发现其通过mTOR通路影响细胞代谢，抗体特异性经siRNA验证。
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**注意事项**：
- 若实际检索文献不足，可查阅抗体生产商(如Abcam、Sigma-Aldrich)的产品说明书，部分会引用相关应用文献。
- 建议通过PubMed或Google Scholar以关键词“CCDC120 antibody”或“CCDC120 + [疾病/功能]”筛选最新研究。
The CCDC120 antibody is a research tool designed to target the Coiled-Coil Domain Containing Protein 120 (CCDC120), a protein encoded by the *CCDC120* gene in humans. While the full biological role of CCDC120 remains under investigation, it is hypothesized to participate in cellular processes involving protein-protein interactions, cytoskeletal organization, or intracellular signaling, owing to its coiled-coil structural motifs. Dysregulation of CCDC120 expression has been preliminarily linked to certain cancers and genetic disorders, though detailed mechanisms are not yet fully elucidated.
The antibody is typically produced in immunized hosts (e.g., rabbits or mice) using immunogens derived from specific epitopes of the CCDC120 protein. It is commonly validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous CCDC120 expression in cell lines or tissue samples. Researchers utilize this reagent to explore CCDC120's subcellular localization, expression patterns across tissues, and potential involvement in disease pathways.
Commercial CCDC120 antibodies often undergo quality checks, including knockout/knockdown validation to confirm specificity. Despite its utility, researchers must consider potential cross-reactivity and batch variability, emphasizing the need for proper controls. Current studies focus on clarifying CCDC120’s functional roles, particularly in cancer biology and developmental processes, to uncover its therapeutic or diagnostic potential.
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