| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Cctz2; CCTZ-2; TSA303; CCT-zeta-2; TCP-1-zeta-2 |
| WB Predicted band size | 58 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CCT6B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下为模拟示例(具体文献需通过学术数据库获取真实信息)：
1. **标题**: "CCT6B as a potential biomarker in breast cancer: overexpression and clinical significance"
**作者**: Smith A, et al.
**摘要**: 研究通过免疫组化及Western blot分析，发现CCT6B在乳腺癌组织中显著高表达，并与患者预后不良相关，提示其作为治疗靶点的潜力。
2. **标题**: "CCT6B antibody application in proteostasis dysfunction studies"
**作者**: Chen L, et al.
**摘要**: 利用CCT6B特异性抗体探究其在神经退行性疾病中的作用，发现CCT6B缺失导致错误折叠蛋白积累，影响神经元存活。
3. **标题**: "CCT6B interacts with oncogenic kinases: Insights from co-immunoprecipitation assays"
**作者**: Wang X, et al.
**摘要**: 通过抗体介导的共免疫沉淀技术，揭示CCT6B与多种激酶(如AKT)的相互作用，可能参与肿瘤信号通路调控。
4. **标题**: "Development of a novel monoclonal antibody against CCT6B for diagnostic applications"
**作者**: Kim H, et al.
**摘要**: 报道一种高特异性抗CCT6B单克隆抗体的开发，验证其在结直肠癌组织中的诊断灵敏性，优于传统标志物。
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**说明**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索(关键词：CCT6B antibody, chaperonin containing TCP1 subunit 6B)。真实研究可能涉及抗体在蛋白质折叠、癌症或神经疾病中的机制。
The CCT6B antibody is designed to target the CCT6B (Chaperonin Containing TCP1 Subunit 6B) protein, a member of the chaperonin-containing TCP-1 (CCT) complex. This evolutionarily conserved complex, also known as TRiC, assists in the folding of newly synthesized polypeptides, particularly actin and tubulin, essential for cytoskeletal integrity and cellular processes. CCT6B, one of eight paralogous subunits (CCT1–8), plays a critical role in substrate recognition and ATP hydrolysis, enabling conformational changes necessary for protein folding.
CCT6B is ubiquitously expressed but shows tissue-specific enrichment, notably in testis, suggesting a role in spermatogenesis. Dysregulation of CCT6B has been implicated in cancers, including hepatocellular carcinoma and glioblastoma, where its overexpression correlates with tumor progression and poor prognosis. Additionally, mutations in CCT6B are linked to neurodevelopmental disorders, highlighting its importance in neuronal function.
Antibodies against CCT6B are widely used in research to study its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. These tools help elucidate mechanisms underlying protein misfolding diseases, cancer biology, and reproductive health. Recent studies also explore CCT6B's potential as a therapeutic target, particularly in malignancies dependent on proper cytoskeletal dynamics. However, challenges remain in distinguishing CCT6B-specific functions from those of other CCT subunits due to structural and functional overlap within the complex.
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