| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CFP1; CGBP; SPP1; PCCX1; PHF18; hCGBP; ZCGPC1; HsT2645; 2410002I16Rik; 5830420C16Rik |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CXXC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CXXC1抗体的3篇参考文献(基于近年研究，文献标题与内容为模拟示例)：
1. **"CXXC1 mediates DNA methylation-independent transcriptional regulation in embryonic stem cells"**
- **作者**: Smith A, et al.
- **摘要**: 本研究利用CXXC1特异性抗体进行ChIP-seq分析，揭示了CXXC1通过结合非甲基化CpG岛调控胚胎干细胞多能性相关基因的机制，表明其在表观遗传调控中的关键作用。
2. **"Antibody-based profiling of CXXC1 reveals its role in maintaining 5hmC levels in leukemia cells"**
- **作者**: Li X, et al.
- **摘要**: 通过Western blot和免疫荧光技术，作者使用CXXC1抗体证明其在急性髓系白血病(AML)细胞中与TET2蛋白相互作用，维持5-羟甲基胞嘧啶(5hmC)水平，影响白血病细胞分化。
3. **"CXXC1 antibody screening identifies its interaction with the SWI/SNF complex in chromatin remodeling"**
- **作者**: Chen Y, et al.
- **摘要**: 本研究通过免疫共沉淀(Co-IP)结合质谱分析，利用CXXC1抗体发现其与SWI/SNF染色质重塑复合物的相互作用，揭示了CXXC1在调控基因转录和细胞周期中的新功能。
**备注**：以上文献为模拟示例，实际文献需通过PubMed或Google Scholar搜索关键词“CXXC1 antibody”或“CXXC1 immunoprecipitation”获取。建议结合具体研究方向筛选实验方法学或疾病机制相关论文。
The CXXC1 antibody is a research tool targeting the CXXC-type zinc finger protein 1 (CXXC1), also known as CFP1 or CGBP. CXXC1 is a nuclear protein containing a conserved CXXC domain that binds unmethylated CpG dinucleotides, enabling its role in epigenetic regulation. It serves as a critical component of the SETD1 histone methyltransferase complex, facilitating H3K4 trimethylation (H3K4me3), a histone modification associated with active gene promoters. CXXC1 also interacts with the TET enzymes, which catalyze DNA demethylation, linking it to DNA methylation dynamics.
CXXC1 is essential for embryonic development and cellular differentiation, influencing processes like hematopoiesis and stem cell maintenance. Dysregulation of CXXC1 is implicated in cancers, particularly leukemias, where aberrant DNA methylation or histone modification patterns contribute to oncogenesis. The CXXC1 antibody is widely used in techniques such as chromatin immunoprecipitation (ChIP), Western blotting, and immunofluorescence to study its localization, protein interactions, and regulatory roles in gene expression. Researchers employ this antibody to explore mechanisms of epigenetic inheritance, DNA repair, and disease-related epigenetic alterations. Its specificity and reliability make it a key reagent in dissecting the interplay between chromatin modifiers, DNA methylation, and transcriptional regulation in health and disease.
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