| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Clathrin light chain A, Lca, CLTA |
| Entrez GeneID | 1211 |
| WB Predicted band size | 27.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CLTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-127 amino acids from the Central region of human CLTA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CHD2抗体相关的文献示例(部分为模拟内容，供参考)：
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1. **文献名称**: *CHD2 regulates neuronal gene expression and is linked to childhood epilepsy*
**作者**: Thomas R. et al.
**摘要**: 本研究通过CHD2特异性抗体进行染色质免疫沉淀(ChIP-seq)，揭示了CHD2在小鼠神经元分化中对关键基因(如*Grin2b*)的调控作用，并发现其突变与癫痫发生相关。
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2. **文献名称**: *Proteomic analysis of CHD2 interaction networks in DNA repair*
**作者**: Chen L. et al.
**摘要**: 利用CHD2抗体进行免疫共沉淀(Co-IP)结合质谱分析，鉴定了CHD2与BRCA1、HDAC1等蛋白的相互作用，表明其在DNA损伤修复通路中的潜在功能。
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3. **文献名称**: *Altered CHD2 expression in autism spectrum disorder models*
**作者**: Martinez D. et al.
**摘要**: 通过Western blot和免疫组化(IHC)结合CHD2抗体，发现自闭症模型小鼠前额叶皮层中CHD2蛋白水平显著降低，提示其表达异常可能与神经发育障碍相关。
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4. **文献名称**: *CHD2 modulates chromatin structure to suppress oncogenic signaling*
**作者**: Kim S. et al.
**摘要**: 研究使用CHD2抗体进行荧光染色和流式分选，证明CHD2通过维持染色质紧缩状态抑制癌细胞增殖，其缺失导致多种促癌基因异常激活。
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注：以上文献为示例性质，实际引用时请核实真实来源及数据准确性。如需真实文献，建议通过PubMed或Google Scholar以“CHD2 antibody” + 研究领域(如epilepsy/cancer)为关键词检索。
The CHD2 (Chromodomain Helicase DNA-Binding Protein 2) antibody is a tool used to study the CHD2 protein, a member of the CHD family of ATP-dependent chromatin remodelers. CHD2 plays a critical role in regulating gene expression by modifying chromatin structure, facilitating DNA accessibility, and interacting with transcription machinery. It contains conserved chromodomains that recognize methylated histones, a helicase domain for ATP hydrolysis, and a DNA-binding domain, enabling its function in nucleosome repositioning and epigenetic regulation.
CHD2 is implicated in neurodevelopment, as mutations are linked to epilepsy, autism spectrum disorders, and intellectual disabilities. It also participates in DNA damage repair, cell differentiation, and tumor suppression, with aberrant expression observed in cancers. Research using CHD2 antibodies focuses on its localization, expression levels, and interactions in cellular and disease models. These antibodies are essential in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP), aiding in mechanistic studies of CHD2-related pathologies. Recent studies highlight its role in maintaining genomic stability and regulating immune responses, expanding its relevance in both developmental and oncogenic contexts. The development of specific CHD2 antibodies has advanced diagnostic and therapeutic research, particularly in neurological and cancer disorders.
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