| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CMH3; TMSA; CMD1Y; C15orf13; HTM-alpha |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TPM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CHAC2抗体的模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **文献名称**: *CHAC2 regulates oxidative stress-induced apoptosis via glutathione metabolism*
**作者**: Smith A, et al.
**摘要**: 本研究利用CHAC2特异性抗体，发现CHAC2通过降解谷胱甘肽调控细胞氧化应激反应，其缺失导致癌细胞凋亡抵抗，提示其作为癌症治疗的潜在靶点。
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2. **文献名称**: *Development and validation of a polyclonal CHAC2 antibody for neurodegenerative disease models*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种新型兔源CHAC2多克隆抗体的开发，验证了其在脑组织中的特异性，并发现CHAC2在阿尔茨海默病模型中表达上调，可能与神经元氧化损伤相关。
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3. **文献名称**: *CHAC2-mediated glutathione homeostasis impacts mitochondrial function in cardiomyocytes*
**作者**: Wang Y, et al.
**摘要**: 通过CHAC2抗体免疫沉淀和Western blot分析，揭示了CHAC2通过调节心肌细胞线粒体谷胱甘肽水平影响心脏缺血再灌注损伤的分子机制。
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**注**：以上内容为示例，实际文献需通过PubMed、Web of Science等平台检索确认。建议结合具体研究方向补充关键词(如“CHAC2 antibody validation”或“CHAC2 glutathione”)进行精准查询。
**Background of CHAC2 Antibody**
The CHAC2 (cation transport regulator-like protein 2) antibody is a tool used to detect and study the CHAC2 protein, a member of the CHAC family of glutathione (GSH)-degrading enzymes. CHAC2. also known as MGC4509. shares structural and functional homology with CHAC1. both of which catalyze the cleavage of glutathione into 5-oxoproline and cysteinylglycine via their γ-glutamylcyclotransferase activity. This process plays a role in regulating intracellular redox balance, impacting cellular responses to oxidative stress, apoptosis, and metabolic pathways.
CHAC2 is ubiquitously expressed but shows tissue-specific variations, with higher levels observed in the liver, kidney, and heart. Its biological significance is linked to diseases involving oxidative damage, such as neurodegenerative disorders, cancer, and cardiovascular conditions. Studies suggest CHAC2 may influence cell survival under stress by modulating GSH levels, though its precise mechanisms remain less characterized compared to CHAC1.
Antibodies against CHAC2 are essential for elucidating its expression patterns, subcellular localization, and interactions in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research utilizing CHAC2 antibodies has contributed to understanding its role in endoplasmic reticulum (ER) stress responses and potential therapeutic targeting in redox-related diseases. Ongoing studies aim to clarify its distinct functions and regulatory networks within cellular antioxidant defense systems.
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