| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与DCTD(脱氧胞苷激酶)抗体相关的文献摘要，供参考：
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1. **文献名称**: *Deoxycytidine kinase is overexpressed in poor prognosis CLL patients and essential for TMD-121 resistance*
**作者**: Zhu C, et al.
**摘要**: 研究利用DCTD抗体检测慢性淋巴细胞白血病(CLL)患者样本，发现DCTD高表达与患者预后不良相关，并通过基因沉默实验证实DCTD在核苷类似物耐药性中的关键作用。
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2. **文献名称**: *DCTD as a biomarker for gemcitabine sensitivity in pancreatic cancer*
**作者**: Kimura M, et al.
**摘要**: 通过免疫组化(使用DCTD抗体)分析胰腺癌组织，发现低DCTD表达与吉西他滨化疗敏感性下降显著相关，提示其可作为个性化治疗的潜在标志物。
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3. **文献名称**: *Development of a novel monoclonal antibody against human DCTD for functional studies*
**作者**: Sato R, et al.
**摘要**: 报道了一种新型DCTD单克隆抗体的开发，验证其特异性后应用于流式细胞术和Western blot，成功检测癌细胞系中DCTD的蛋白水平差异，并用于药物代谢机制研究。
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如需具体文献来源或补充更多研究，可进一步说明需求。
DCTD (dCMP deaminase) is a crucial enzyme in nucleotide metabolism, catalyzing the deamination of deoxycytidine monophosphate (dCMP) to deoxyuridine monophosphate (dUMP), a rate-limiting step in thymidylate biosynthesis. This reaction supports DNA synthesis and repair, linking DCTD to cell proliferation and genomic stability. Dysregulation of DCTD has been implicated in cancer progression, chemotherapy resistance, and immune evasion due to its role in maintaining nucleotide pool balance.
Anti-DCTD antibodies are essential tools for studying the enzyme's expression, localization, and function in biological systems. They enable detection and quantification of DCTD protein levels in tissues or cell lines using techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers utilize these antibodies to explore DCTD's involvement in cancer biology, particularly its overexpression in certain malignancies and potential as a therapeutic target. Some studies suggest DCTD inhibition could enhance the efficacy of antimetabolite drugs like 5-fluorouracil by disrupting pyrimidine salvage pathways. Commercial DCTD antibodies are typically developed in rabbit or mouse hosts, validated for specificity through knockout controls. Recent investigations also examine DCTD's non-canonical roles in viral replication and autoimmune disorders, expanding its biomedical relevance. Proper antibody validation remains critical given sequence homology with other deaminase family members.
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