Rabbit Polyclonal DENND5A Antibody

The DENND5A antibody targets the DENN Domain Containing 5A (DENND5A) protein, a member of the DENN domain-containing protein family implicated in regulating intracellular membrane trafficking and vesicle transport. DENND5A, also known as Rab6-interacting protein 1 (Rab6IP1), interacts with Rab GTPases, particularly Rab6. to modulate Golgi-associated vesicular transport and endosomal sorting. The protein features a conserved DENN domain, which facilitates guanine nucleotide exchange factor (GEF) activity, enabling Rab protein activation and subsequent recruitment of effector molecules. DENND5A is ubiquitously expressed, with roles in maintaining Golgi structure, secretory pathways, and neuronal development. Antibodies against DENND5A are widely used in research to investigate its localization, expression levels, and interactions in cellular models. They are essential tools for Western blotting, immunofluorescence, and immunohistochemistry to study DENND5A's involvement in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. Additionally, these antibodies help elucidate molecular mechanisms underlying vesicle trafficking defects linked to DENND5A dysregulation. Commercial DENND5A antibodies are typically raised in rabbits or mice, validated for specificity across human, mouse, and rat samples, and may detect multiple isoforms due to alternative splicing. Their application continues to advance understanding of intracellular transport pathways and related pathologies.