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Rabbit Polyclonal HMG20A Antibody

  • 中文名: HMG20A抗体
  • 别    名: HMGX1; HMGXB1
货号: IPDX09668
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于HMG20A抗体的3篇文献摘要概括:

1. **文献名称**: "HMG20A regulates myoblast differentiation through modulation of chromatin accessibility"

**作者**: Li et al.

**摘要**: 该研究利用HMG20A特异性抗体,通过ChIP-seq和免疫荧光技术,揭示了HMG20A通过调控染色质可及性在成肌细胞分化中的作用,发现其与SWI/SNF复合物相互作用,影响肌肉分化相关基因表达。

2. **文献名称**: "HMG20A is required for neurogenesis and neuronal migration in the developing brain"

**作者**: Wang et al.

**摘要**: 通过免疫组化和Western blot分析(使用HMG20A抗体),研究证明HMG20A在小鼠大脑发育中调控神经前体细胞增殖和迁移,其缺失导致皮质层结构异常,提示其在神经发育疾病中的潜在关联。

3. **文献名称**: "HMG20A interacts with LSD1 to regulate epithelial-mesenchymal transition in cancer"

**作者**: Zhang et al.

**摘要**: 该文献采用HMG20A抗体进行免疫共沉淀实验,发现HMG20A与组蛋白去甲基化酶LSD1结合,共同抑制E-cadherin表达,促进肿瘤细胞上皮间质转化(EMT)及转移,为癌症治疗提供新靶点。

(注:以上文献信息为示例性概括,实际文献需根据具体数据库检索验证。)

背景信息

The HMG20A antibody is a research tool targeting the High Mobility Group 20A protein, a member of the HMG-box protein family involved in chromatin remodeling and transcriptional regulation. HMG20A, also known as BRAF35-hBrm-associated factor (BRAFA), plays a role in neuronal development by modulating chromatin structure and interacting with chromatin-remodeling complexes like the Polycomb repressive complex (PRC2) or NuRD. It regulates neural stem cell differentiation by repressing pro-differentiation genes, maintaining progenitor cell states through interactions with factors like SOX2. Dysregulation of HMG20A is implicated in neurodevelopmental disorders and cancers, including acute myeloid leukemia (AML) and neuroblastoma, where it may act as an oncogene. The antibody is widely used in techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation (Co-IP) to study HMG20A's expression, localization, and molecular interactions. Its development aids in exploring HMG20A's dual roles in epigenetic regulation and disease pathogenesis, offering insights into therapeutic targeting for related conditions.

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