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Rabbit Polyclonal REG1B Antibody

  • 中文名: REG1B抗体
  • 别    名: REGH; REGL; PSPS2; REGI-BETA
货号: IPDX10105
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesREGH; REGL; PSPS2; REGI-BETA
WB Predicted band size19 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human REG1B
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于REG1B抗体的3篇参考文献及其摘要内容概括:

1. **文献名称**:*REG1B as a Novel Biomarker for Pancreatic Cancer Detection: Development of a Monoclonal Antibody-Based ELISA*

**作者**:Li, Y. et al.

**摘要**:该研究开发了一种针对REG1B蛋白的单克隆抗体,并基于此建立了高灵敏度的ELISA检测方法,用于胰腺癌患者血清中REG1B的定量分析。结果显示,REG1B在早期胰腺癌患者中显著升高,提示其作为诊断标志物的潜力。

2. **文献名称**:*Immunohistochemical Analysis of REG1B in Gastrointestinal Tissues Using a Novel Polyclonal Antibody*

**作者**:Tanaka, M. et al.

**摘要**:研究团队制备了一种兔源多克隆抗体,用于检测胃肠道组织中的REG1B蛋白表达。实验表明,REG1B在慢性炎症和癌前病变组织中高表达,提示其可能参与黏膜修复和肿瘤发生过程。

3. **文献名称**:*REG1B Autoantibodies as a Serological Marker for Type 1 Diabetes Progression*

**作者**:Zhang, H. et al.

**摘要**:该研究发现,1型糖尿病患者血清中存在针对REG1B的自身抗体,且抗体水平与胰岛β细胞损伤程度相关。通过蛋白芯片和Western blot验证了抗体的特异性,为疾病监测提供了新思路。

注:上述文献信息为示例性质,实际文献需通过学术数据库检索确认。

背景信息

The REG1B antibody targets the REG1B protein, a member of the regenerating islet-derived (REG) family, which plays roles in cell proliferation, regeneration, and inflammation. REG1B, also known as lithostathine-1β or pancreatic stone protein, is secreted primarily by pancreatic acinar cells and gastrointestinal tissues. It functions as a C-type lectin, potentially involved in calcium carbonate crystal inhibition, mucosal repair, and microbial defense. Dysregulation of REG1B is linked to pancreatic diseases (e.g., chronic pancreatitis, diabetes) and cancers (e.g., colorectal, gastric). The REG1B antibody is utilized in research to detect REG1B expression in tissues or biological fluids, aiding in understanding its pathological roles. It is critical for immunoassays (ELISA, immunohistochemistry) and functional studies exploring REG1B's interaction with receptors like EXTL3. Specificity and validation are essential due to homology with REG1A.

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