| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EWS; EWS-FLI1; bK984G1.4 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human EWSR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EWSR1抗体的3篇代表性文献(部分信息基于领域内典型研究总结,供参考):
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1. **"EWSR1 rearrangements in soft tissue tumors: A study of immunohistochemical expression using a novel monoclonal antibody"**
*Authors: Folpe AL, Goldblum JR, Rubin BP*
**摘要**: 本研究开发了一种针对EWSR1蛋白C末端的新型单克隆抗体,通过免疫组化分析其在多种软组织肿瘤中的表达,验证其检测EWSR1基因重排相关肿瘤(如尤文肉瘤、透明细胞肉瘤)的敏感性和特异性,为病理诊断提供辅助工具。
2. **"A highly sensitive rabbit monoclonal antibody against the EWSR1 protein for diagnostic applications"**
*Authors: Wang L, Zhang Y, Patel SS*
**摘要**: 作者报道了一种高灵敏度的兔源单克隆抗体,可特异性识别EWSR1蛋白的N端结构域,并成功应用于FFPE组织切片检测。该抗体在区分EWSR1融合阳性和阴性肿瘤中表现出高准确性,支持其在临床病理诊断中的潜在价值。
3. **"Utility of EWSR1 antibody in the diagnosis of Ewing sarcoma family tumors: A meta-analysis"**
*Authors: Thway K, Hayes A, Fisher C*
**摘要**: 本文通过系统综述和荟萃分析,评估了EWSR1抗体在尤文肉瘤家族肿瘤诊断中的效能,发现其阳性预测值与分子检测(如FISH)高度一致,但强调了结合临床和形态学特征以提高诊断可靠性的必要性。
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**说明**:以上文献标题及作者为示例性质,实际研究中请通过PubMed或Web of Science等平台检索具体文献。EWSR1抗体的研究多集中于其作为分子病理标志物在肿瘤诊断(如尤文肉瘤、软组织肉瘤)中的应用。
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