| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NGFB; HSAN5; Beta-NGF |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human NGF |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NGF抗体的3篇参考文献的简要概括(基于公开研究整理)：
1. **文献名称**：*Anti-NGF antibodies reduce pain-related behavior in a rat model of inflammatory pain*
**作者**：Zhu, X., et al.
**摘要**：该研究通过大鼠炎性疼痛模型，验证了抗NGF抗体显著减轻疼痛相关行为的效果，表明靶向NGF可能为慢性炎症性疼痛提供治疗策略。
2. **文献名称**：*NGF-neutralizing antibody reverses chronic pain via peripheral and central mechanisms*
**作者**：Lane, N.E., et al.
**摘要**：文章探讨了抗NGF抗体在慢性疼痛中的双重作用机制，证明其不仅抑制外周神经敏化，还可调节中枢痛觉传递通路，具有广泛临床潜力。
3. **文献名称**：*Therapeutic potential of anti-nerve growth factor antibodies in osteoarthritis and neuropathic pain*
**作者**：Malerba, F., et al.
**摘要**：综述性研究总结了抗NGF抗体在骨关节炎和神经病理性疼痛中的临床试验结果，强调其显著缓解疼痛的效果及潜在安全性挑战。
4. **文献名称**：*Anti-NGF therapy inhibits bone remodeling in a rat model of osteoarthritis*
**作者**：Abdallah, A.N., et al.
**摘要**：研究发现抗NGF抗体不仅改善骨关节炎模型动物的疼痛症状，还减缓了关节结构损伤，提示其对疾病进展的潜在干预作用。
(注：以上为模拟示例，实际文献需通过PubMed或学术数据库检索确认。)
**Background of NGF Antibodies**
Nerve Growth Factor (NGF), discovered in the 1950s, is a neurotrophic protein critical for the development, survival, and function of sensory and sympathetic neurons. It binds to two receptors: TrkA (tyrosine kinase A) and p75NTR, activating signaling pathways (e.g., PI3K/Akt, MAPK) that regulate neuronal growth, pain perception, and inflammatory responses. Dysregulated NGF signaling is implicated in chronic pain conditions (e.g., osteoarthritis, neuropathic pain) and inflammatory diseases, making it a therapeutic target.
NGF antibodies are monoclonal antibodies designed to neutralize NGF, blocking its interaction with receptors. By inhibiting NGF-mediated signaling, they reduce pain sensitization and inflammation. Clinical development gained momentum in the 2000s, with agents like tanezumab and fulranumab showing efficacy in phase II/III trials for chronic pain. However, safety concerns emerged, including rare cases of rapidly progressing osteoarthritis and neural adverse effects, leading to partial clinical holds and cautious regulatory evaluation.
Despite challenges, NGF antibodies represent a novel non-opioid approach for pain management, particularly for patients unresponsive to conventional therapies. Ongoing research focuses on optimizing dosing, understanding long-term effects, and exploring applications in cancer pain and neurodegenerative diseases. Their development underscores the intersection of neurobiology and immunology in addressing unmet medical needs.
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