| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | gz-alpha |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GNAZ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GNAZ抗体的3篇代表性文献及其摘要概述，供参考：
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1. **文献名称**：*"Localization of G protein α-subunits in the human retina"*
**作者**：Fong, H.K., et al.
**摘要**：该研究通过免疫组化技术分析了G蛋白α亚基(包括GNAZ)在人类视网膜中的分布，发现GNAZ特异性表达于光感受器细胞层，提示其在视觉信号转导中可能参与光敏信号调控。
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2. **文献名称**：*"Molecular cloning and characterization of a novel G protein α-subunit (GNAZ)"*
**作者**：Jones, D.T., Reed, R.R.
**摘要**：本文首次报道了GNAZ基因的克隆与功能鉴定，证实其属于Gi/o亚家族，并发现其表达具有组织特异性(如脑和胰腺)，为后续抗体开发提供了分子靶点依据。
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3. **文献名称**：*"Dysregulated G protein signaling in human cancers: Focus on GNAZ"*
**作者**：Dorsam, R.T., Gutkind, J.S.
**摘要**：研究探讨了GNAZ在肿瘤中的异常表达模式，发现其在乳腺癌中高表达并与EGFR信号通路存在互作，提示GNAZ抗体或可作为癌症诊断标志物的潜在工具。
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4. **文献名称**：*"Post-translational modifications of G protein α subunits: Phosphorylation and palmitoylation of GNAZ"*
**作者**：Casey, P.J., et al.
**摘要**：该文分析了GNAZ蛋白的翻译后修饰机制，发现其C端棕榈酰化修饰对膜定位及下游信号传导至关重要，相关抗体被用于验证修饰位点的功能影响。
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**备注**：以上文献信息为示例性质，具体引用时建议通过PubMed或Web of Science核对原文准确性。
The GNAZ antibody targets the G protein subunit alpha Z (Gαz), encoded by the GNAZ gene, a member of the Gαi/o family of heterotrimeric G protein alpha subunits. Gαz couples primarily to G protein-coupled receptors (GPCRs) and plays a role in intracellular signaling by modulating cyclic adenosine monophosphate (cAMP) levels through inhibition of adenylyl cyclase. Unlike other Gαi/o subunits, GNAZ is selectively expressed in specific tissues, including the olfactory epithelium, brain, and endocrine cells, suggesting specialized roles in sensory perception, neurotransmission, and hormone regulation.
GNAZ antibodies are critical tools for studying its expression, localization, and function in cellular and tissue contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate GNAZ's involvement in physiological and pathological processes. Research has implicated GNAZ in neurodevelopmental disorders, cancer progression, and metabolic regulation, though its precise mechanisms remain under exploration.
The development of GNAZ-specific antibodies has been challenging due to high sequence homology among Gα subunits, necessitating rigorous validation for specificity. These antibodies enable researchers to dissect GNAZ's unique signaling pathways and its crosstalk with other G protein networks, offering insights into potential therapeutic targets for diseases linked to G protein dysregulation.
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