| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DE; SPD; BDSD; HOX4I |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXD13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXD13抗体的3篇参考文献示例(内容基于公开研究概括，非真实文献，仅供示例参考)：
1. **文献名称**：*HOXD13 Antibody Characterization in Limb Development Studies*
**作者**：Smith J, et al.
**摘要**：本研究通过HOXD13抗体的免疫组化分析，揭示了其在小鼠胚胎肢体发育中的时空表达模式，证实HOXD13在前肢和后肢的远端结构(如指/趾)形成中起关键调控作用。
2. **文献名称**：*Mutation Screening and HOXD13 Antibody Staining in Human Synpolydactyly*
**作者**：Lee S, et al.
**摘要**：利用HOXD13抗体对多指/趾畸形患者组织样本进行染色，发现HOXD13蛋白表达异常与基因突变相关，提示其功能缺失可能导致肢体形态发育障碍。
3. **文献名称**：*HOXD13 in Vertebrate Evolution: Antibody-Based Comparative Analysis*
**作者**：Garcia R, et al.
**摘要**：通过跨物种HOXD13抗体标记实验，比较了鱼类、鸟类和哺乳动物中的表达差异，支持HOXD13在脊椎动物肢体多样性进化中的保守性和功能特异性。
(注：以上文献为虚拟示例，实际引用需查询PubMed、Web of Science等数据库获取真实研究。)
The HOXD13 antibody is a crucial tool in developmental biology and genetic research, targeting the HOXD13 protein encoded by the *HOXD13* gene, a member of the homeobox (HOX) gene family. HOX genes are evolutionarily conserved regulators of embryonic development, particularly in establishing body patterning and limb formation. HOXD13. located on chromosome 2q31. plays a pivotal role in autopod (distal limb) development and digit specification, as well as urogenital system morphogenesis. Mutations in *HOXD13* are linked to human disorders such as synpolydactyly (SPD) and hand-foot-genital syndrome (HOS), characterized by limb malformations and genital abnormalities.
The HOXD13 antibody is widely used to detect and quantify HOXD13 protein expression in various experimental models, including immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). It aids in studying HOXD13's spatial-temporal expression during embryogenesis, its interaction with signaling pathways (e.g., SHH, FGF), and its role in transcriptional regulation of target genes. Researchers also employ this antibody to investigate HOXD13 dysregulation in congenital defects, cancer (e.g., leukemia, colorectal cancer), and regenerative processes. Both polyclonal and monoclonal variants are available, with validation often performed using knockout controls or overexpression systems. Its utility extends to diagnostic applications, helping correlate genetic mutations with phenotypic outcomes in clinical samples.
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