| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IGFBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IGFBP1抗体的3篇示例文献(虚构示例，仅供格式参考)：
1. **文献名称**：*"Development of a High-Specificity IGFBP1 Antibody for Gestational Diabetes Biomarker Detection"*
**作者**：Smith J, et al.
**摘要**：研究开发了一种高特异性IGFBP1单克隆抗体，用于妊娠糖尿病患者的血清检测，验证了其在ELISA中的灵敏度和临床样本中的相关性。
2. **文献名称**：*"IGFBP1 Polyclonal Antibody Application in Hepatic Fibrosis Model Analysis"*
**作者**：Lee H, et al.
**摘要**：通过免疫组化和Western blot技术，利用IGFBP1多克隆抗体揭示了肝纤维化小鼠模型中IGFBP1的表达上调及其与胰岛素抵抗的关联。
3. **文献名称**：*"Comparative Study of Commercial IGFBP1 Antibodies in Cancer Cell Line Profiling"*
**作者**：Garcia R, et al.
**摘要**：比较了5种市售IGFBP1抗体在乳腺癌细胞系中的检测性能，确定了两种抗体在流式细胞术和免疫荧光中的高一致性。
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注：以上为模拟文献，实际引用需通过PubMed、Google Scholar等平台检索真实发表的研究。
Insulin-like growth factor-binding protein 1 (IGFBP1) is a key member of the IGFBP family, which regulates the bioavailability and activity of insulin-like growth factors (IGFs) by binding to IGF-1 and IGF-2. Primarily synthesized in the liver and decidualized endometrial cells, IGFBP1 modulates cell growth, metabolism, and differentiation by controlling IGF interactions with their receptors. Its expression is influenced by metabolic and hormonal signals, such as insulin, glucocorticoids, and hypoxia, making it a dynamic player in conditions like gestational diabetes, intrauterine growth restriction, and insulin resistance.
IGFBP1 antibodies are essential tools for studying its biological roles and clinical applications. These antibodies, often generated in rabbits or mice using recombinant IGFBP1 protein, enable detection and quantification of IGFBP1 in immunoassays (e.g., ELISA, Western blot) and tissue localization via immunohistochemistry. Specificity varies depending on epitope recognition; some antibodies target N-terminal domains critical for IGF binding, while others detect phosphorylated isoforms linked to functional regulation. In research, IGFBP1 antibodies help elucidate mechanisms in fetal development, metabolic disorders, and cancers where IGF signaling is dysregulated. Clinically, they aid in diagnosing pregnancy-related complications or evaluating IGFBP1 as a biomarker in conditions like polycystic ovary syndrome (PCOS) or liver fibrosis. Recent studies also explore IGFBP1's role in inflammation and aging, broadening its therapeutic relevance.
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