| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | AGM, PSF, TAF, FSTL2, IBP-7, MAC25, IGFBP-7, RAMSVPS, IGFBP-7v, IGFBPRP1 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IGFBP7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IGFBP7抗体的3篇参考文献的简要概括：
1. **文献名称**：*IGFBP7 as a biomarker in hepatocellular carcinoma: A tissue microarray study*
**作者**：Chen Y. et al.
**摘要**：通过免疫组化分析肝癌组织中IGFBP7蛋白表达，发现其高表达与患者预后不良相关，提示IGFBP7抗体可作为潜在诊断标志物。
2. **文献名称**：*Targeting IGFBP7 in renal fibrosis: Antibody-based inhibition attenuates disease progression*
**作者**：Kim S. et al.
**摘要**：研究开发了特异性IGFBP7中和抗体，并在小鼠模型中验证其抑制TGF-β信号通路、减轻肾纤维化的治疗效果。
3. **文献名称**：*Development of a high-sensitivity ELISA for IGFBP7 detection in plasma*
**作者**：Wang L. et al.
**摘要**：报道一种基于单克隆IGFBP7抗体的新型ELISA检测方法，灵敏度达pg/mL级别，适用于心血管疾病患者的早期筛查。
4. **文献名称**：*IGFBP7 regulates angiogenesis in diabetic retinopathy via VEGF interaction*
**作者**：Garcia-Ruiz A. et al.
**摘要**：利用IGFBP7抗体阻断实验，揭示IGFBP7通过调控VEGF通路促进视网膜新生血管生成，为治疗提供新靶点。
(注：以上文献为示例，实际引用需根据具体研究核实信息。)
IGFBP7 (Insulin-like Growth Factor Binding Protein 7) is a secreted protein belonging to the IGFBP superfamily, though it exhibits low affinity for IGFs and instead modulates insulin-like growth factor (IGF) signaling and interacts with other pathways, including TGF-β. It plays roles in cell proliferation, apoptosis, senescence, and angiogenesis. Dysregulation of IGFBP7 is implicated in various diseases, including cancer, fibrosis, and metabolic disorders. In cancer, IGFBP7 acts as a context-dependent tumor suppressor or promoter, influencing metastasis and therapy resistance. It is also linked to cellular senescence through its association with the senescence-associated secretory phenotype (SASP).
IGFBP7 antibodies are essential tools for detecting and quantifying IGFBP7 in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study IGFBP7 expression patterns, localization, and interactions in tissues or biofluids. Such antibodies aid in exploring its biological functions, mechanisms in disease progression, and potential as a therapeutic target or biomarker. For example, elevated IGFBP7 levels in blood or urine have been proposed as biomarkers for conditions like diabetic nephropathy or cancer prognosis. Additionally, neutralizing antibodies targeting IGFBP7 are under investigation for modulating its activity in pathological contexts, such as tumor microenvironments or fibrotic tissues. Research utilizing IGFBP7 antibodies continues to clarify its dual roles in health and disease.
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