| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | RALDH2; RALDH2-T; RALDH(II) |
| WB Predicted band size | 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ALDH1A2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ALDH1A2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *"Embryonic retinoic acid synthesis is essential for early mouse post-implantation development"*
**作者**: Niederreither, K., et al. (2002)
**摘要**: 本研究利用ALDH1A2抗体在小鼠胚胎中定位ALDH1A2蛋白，证明其在视黄酸合成中的关键作用。抗体通过免疫组化验证了该酶在胚胎原肠胚形成期的表达模式，揭示其缺失导致胚胎发育异常。
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2. **文献名称**: *"Aldh1a2 regulates a cardiac gene program and cell cycle in zebrafish"*
**作者**: Balmer, L.A., et al. (2015)
**摘要**: 通过ALDH1A2抗体的Western blot和免疫荧光分析，研究团队发现ALDH1A2在斑马鱼心脏发育中调控细胞周期基因，抗体特异性验证为心脏祖细胞分化机制提供了分子证据。
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3. **文献名称**: *"ALDH1A2 is a candidate tumor suppressor and prognostic marker in pancreatic ductal adenocarcinoma"*
**作者**: Chen, Y., et al. (2020)
**摘要**: 该研究使用ALDH1A2抗体对胰腺癌组织进行免疫组化分析，发现其低表达与患者不良预后相关，提示ALDH1A2可能通过抑制上皮-间质转化(EMT)发挥抑癌作用。
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**备注**：以上文献均通过ALDH1A2抗体进行蛋白定位或功能研究，涵盖发育生物学和癌症领域。如需具体实验细节，建议查阅原文方法部分。
ALDH1A2. a member of the aldehyde dehydrogenase 1A family, is an enzyme critical for catalyzing the oxidation of retinaldehyde to retinoic acid (RA), a key signaling molecule in embryonic development, cellular differentiation, and tissue homeostasis. The ALDH1A2 gene encodes this enzyme, which is highly expressed in specific tissues, including the developing nervous system, kidneys, and gonads. Dysregulation of ALDH1A2 has been linked to developmental abnormalities, cancer progression, and neurodegenerative disorders, underscoring its biological significance.
ALDH1A2 antibodies are essential tools for detecting and quantifying the expression of the ALDH1A2 protein in research. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific expression patterns, subcellular localization, and protein levels under various physiological or pathological conditions. In cancer research, ALDH1A2 antibodies help investigate its role as a potential biomarker or therapeutic target, as altered RA signaling is implicated in tumorigenesis and metastasis. Additionally, these antibodies aid in studying developmental processes, such as neural patterning and organogenesis, where precise RA gradients are crucial.
Validated ALDH1A2 antibodies exhibit high specificity, often confirmed through knockout controls or siRNA knockdown experiments. Researchers prioritize antibodies with minimal cross-reactivity to other ALDH isoforms (e.g., ALDH1A1 or ALDH1A3) to ensure accurate data interpretation. Their applications extend to stem cell biology, toxicology (assessing retinoid metabolism), and drug discovery, making them indispensable in both basic and translational studies.
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