Rabbit Polyclonal ALDH1B1 Antibody

The ALDH1B1 antibody is a crucial tool for studying the aldehyde dehydrogenase 1B1 (ALDH1B1) enzyme, a member of the aldehyde dehydrogenase superfamily involved in detoxifying endogenous and exogenous aldehydes. ALDH1B1 is primarily localized to mitochondria and plays a role in cellular metabolism, particularly in oxidizing retinaldehyde to retinoic acid, which regulates cell differentiation and development. Its expression is tissue-specific, with high levels observed in the liver, pancreas, and intestinal tissues, suggesting roles in metabolic homeostasis and detoxification. Research has linked ALDH1B1 to several pathological conditions, including cancer (e.g., colorectal, pancreatic), diabetes, and oxidative stress-related disorders, where its dysregulation may contribute to disease progression. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ALDH1B1 expression patterns, subcellular localization, and variations across tissues or disease states. It also aids in exploring ALDH1B1's functional interactions in stem cell biology and mitochondrial metabolism. As ALDH1B1 emerges as a potential biomarker or therapeutic target, the antibody remains essential for validating its role in both normal physiology and disease mechanisms, enabling advancements in diagnostic and therapeutic strategies.