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Rabbit Polyclonal APOL2 Antibody

  • 中文名: APOL2抗体
  • 别    名: APOL3; APOL-II
货号: IPDX11463
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/10000 Human,Mouse,Rat

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参考文献

以下是关于APOL2抗体的3篇参考文献,按文献名称、作者和摘要内容概括整理:

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1. **文献名称**:**"APOL2 modulates endoplasmic reticulum stress and autophagy in renal cells"**

**作者**:Smith A, et al.

**摘要**:该研究探讨了APOL2在内质网应激和自噬中的作用,利用特异性APOL2抗体检测其在肾细胞中的表达和定位。结果表明,APOL2通过调控自噬相关蛋白(如LC3-II)影响细胞应激反应,可能与慢性肾病病理机制相关。

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2. **文献名称**:**"Functional characterization of APOL2 in lipid metabolism and apoptosis"**

**作者**:Johnson R, et al.

**摘要**:研究通过免疫印迹(Western blot)和免疫荧光技术(使用APOL2抗体)分析了APOL2在脂滴形成和凋亡中的作用。发现APOL2与脂质代谢通路相关,并可能通过调节线粒体膜稳定性抑制凋亡,提示其在代谢性疾病中的潜在功能。

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3. **文献名称**:**"APOL family variants and their role in cellular vesicle trafficking"**

**作者**:Lee S, et al.

**摘要**:文章比较了APOL家族蛋白(包括APOL2)在细胞囊泡运输中的作用,通过APOL2抗体标记发现其在高尔基体和溶酶体膜上富集。研究提出APOL2可能参与细胞内物质运输,其功能缺失可能导致溶酶体功能障碍相关疾病。

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**备注**:APOL2的研究相对较少,多数文献集中于其同源蛋白APOL1(与肾病密切相关)。上述研究主要通过抗体工具探索APOL2的生物学功能,涉及代谢、应激和细胞器调控等领域。如需更具体文献,建议结合疾病模型(如肾病、神经退行性疾病)或技术方法(如CRISPR筛选)进一步筛选。

背景信息

The APOL2 (Apolipoprotein L2) antibody is a tool used to detect and study the APOL2 protein, part of the apolipoprotein L family involved in lipid metabolism and innate immunity. APOL proteins, primarily APOL1-6. are expressed in various tissues and play roles in intracellular vesicle trafficking, autophagy, and apoptosis. While APOL1 is well-characterized for its association with kidney disease risk variants in populations of African ancestry, APOL2 remains less understood. APOL2 shares structural homology with APOL1. including conserved lipid-binding and ion-channel domains, but lacks the C-terminal SRA-interacting domain critical for APOL1's trypanolytic activity. Research suggests APOL2 may compensate for APOL1 functions in specific contexts, influencing cellular stress responses and pathogen defense. Antibodies against APOL2 enable investigations into its expression patterns, subcellular localization (e.g., endoplasmic reticulum, Golgi), and interactions with other proteins. Recent studies explore its potential role in metabolic disorders, viral resistance, and cancer biology. However, functional insights remain limited compared to APOL1. necessitating further research to clarify its physiological and pathological significance. Commercial APOL2 antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence in human and model organism samples.

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