| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1 |
| Entrez GeneID | 5669 |
| clone | 5C6G7 |
| WB Predicted band size | 47.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PSG1 (AA: 250-419) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于APOBEC2抗体的参考文献及其摘要要点：
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1. **文献名称**: *APOBEC2 deficiency causes mitochondrial defects and exacerbates cardiac injury after myocardial infarction*
**作者**: Li, M., et al. (2020)
**摘要**: 本研究利用特异性APOBEC2抗体验证了其在心肌细胞中的表达，发现APOBEC2缺失会导致线粒体功能异常，并通过Western blot和免疫组化证明其与心肌梗死后的氧化应激相关。
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2. **文献名称**: *Characterization of APOBEC2 knockout mice reveals a role in skeletal muscle development*
**作者**: Sato, Y., et al. (2017)
**摘要**: 通过定制APOBEC2多克隆抗体，作者发现APOBEC2在小鼠骨骼肌分化中高表达，抗体用于免疫沉淀实验证实其与肌细胞分化调控因子(如MyoD)存在相互作用。
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3. **文献名称**: *Structural insights into APOBEC2-mediated RNA editing and its inhibition by small molecules*
**作者**: Chen, Z., et al. (2021)
**摘要**: 研究使用APOBEC2单克隆抗体进行冷冻电镜结构解析，揭示了APOBEC2结合RNA的分子机制，并筛选出抑制其编辑活性的化合物，为靶向治疗提供依据。
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4. **文献名称**: *APOBEC2 expression correlates with tumor progression in hepatocellular carcinoma*
**作者**: Wang, H., et al. (2019)
**摘要**: 通过免疫组织化学(IHC)和APOBEC2抗体检测肝癌样本，发现APOBEC2高表达与患者预后不良相关，提示其可能作为肝癌的新型生物标志物。
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注：上述文献为示例，实际引用时需核对真实发表信息。如需具体文献DOI或期刊名称，建议通过PubMed或Google Scholar以“APOBEC2 antibody”为关键词检索最新研究。
APOBEC2 (apolipoprotein B mRNA-editing enzyme catalytic subunit 2) is a member of the APOBEC protein family, which consists of cytidine deaminases involved in RNA/DNA editing and innate immunity. Unlike other APOBEC members (e.g., APOBEC3G) known for antiviral roles, APOBEC2 lacks direct nucleic acid-editing activity in humans and displays distinct physiological functions. It is primarily expressed in skeletal muscle, heart, and liver tissues, suggesting tissue-specific roles in development, metabolism, or cellular homeostasis. Structural studies reveal APOBEC2 forms homodimers and may regulate lipid metabolism or muscle differentiation through protein-protein interactions rather than enzymatic editing.
Antibodies targeting APOBEC2 are critical research tools for elucidating its biological functions. They enable detection of endogenous APOBEC2 expression via Western blotting, immunohistochemistry, or immunofluorescence, aiding spatial-temporal localization studies in tissues. Some antibodies also support investigations into APOBEC2’s interaction partners and post-translational modifications. Research links APOBEC2 to metabolic disorders, muscular dystrophies, and cancer progression, though its exact mechanisms remain unclear. Commercial APOBEC2 antibodies are typically raised against conserved epitopes in humans/mice, validated for specificity using knockout controls. Challenges include limited commercial availability and cross-reactivity risks with homologous APOBEC members. Ongoing studies using these antibodies aim to clarify APOBEC2’s role in development and disease, potentially informing therapeutic strategies.
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