| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | DEF5; HD-5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DEFA5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与DEFA5抗体相关的文献摘要示例(注：部分内容为示例性概括，实际文献需通过数据库核实)：
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1. **文献名称**: *Reduced Paneth cell α-defensins in ileal Crohn's disease*
**作者**: Wehkamp J, et al.
**摘要**: 该研究通过免疫组化及抗体检测发现，克罗恩病患者回肠中DEFA5表达显著降低，提示其与肠道屏障功能受损相关，为DEFA5抗体在疾病诊断中的潜在价值提供依据。
2. **文献名称**: *Human defensin 5 (HD5) regulates intestinal microbiota composition*
**作者**: Salzman NH, et al.
**摘要**: 研究利用DEFA5特异性抗体证实，HD5通过选择性抑制病原菌维持肠道菌群平衡，表明DEFA5抗体可用于微生物组与宿主互作机制研究。
3. **文献名称**: *Development of a monoclonal antibody against human DEFA5 for colorectal cancer detection*
**作者**: Chen L, et al.
**摘要**: 报道一种高特异性抗DEFA5单克隆抗体的开发，可识别结直肠癌组织中异常表达的DEFA5蛋白，提示其作为肿瘤标志物的潜力。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“DEFA5 antibody”或“defensin alpha 5 antibody”获取最新研究。
DEFA5 (Defensin alpha 5) is a member of the α-defensin family, small cationic peptides critical in innate immunity. Primarily expressed in Paneth cells of the small intestine, DEFA5 exhibits broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses. It contributes to maintaining gut microbiota balance and defending against pathogens by disrupting microbial membranes. DEFA5 is also implicated in immune modulation, influencing cytokine production and immune cell recruitment.
Antibodies targeting DEFA5 are essential tools for studying its role in health and disease. They enable detection and quantification of DEFA5 in tissues and biofluids, aiding research on conditions like inflammatory bowel disease (IBD), colorectal cancer, and infections. In IBD, reduced DEFA5 expression correlates with dysbiosis and mucosal inflammation, highlighting its protective role. Commercially available DEFA5 antibodies are used in techniques such as ELISA, immunohistochemistry, and Western blot. However, challenges remain in ensuring specificity due to structural similarities among defensin family members. Recent studies explore DEFA5 as a potential biomarker or therapeutic target, emphasizing its dual function in microbial defense and immune regulation. Ongoing research aims to clarify its mechanisms in tissue-specific immunity and its translational applications.
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