| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CBP; LIP4; MCG10 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PCBP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PCBP4抗体的3篇参考文献示例(文献信息为假设性概括，供参考)：
1. **文献名称**：*PCBP4 suppresses tumor progression by inhibiting cell proliferation in non-small cell lung cancer*
**作者**：Zhang Y, et al.
**摘要**：本研究利用PCBP4特异性抗体通过Western blot和免疫组化分析，发现PCBP4在肺癌组织中表达下调，其缺失促进癌细胞增殖，表明PCBP4可能作为肿瘤抑制因子发挥作用。
2. **文献名称**：*Poly(rC)-binding protein 4 interacts with the stress granule marker TIA-1 and regulates cellular stress response*
**作者**：Wang L, et al.
**摘要**：通过免疫共沉淀和免疫荧光技术(使用PCBP4抗体)，揭示了PCBP4在DNA损伤应激下与TIA-1共定位，调控应激颗粒形成，影响细胞存活。
3. **文献名称**：*PCBP4 modulates hepatitis B virus replication by binding viral RNA*
**作者**：Liu X, et al.
**摘要**：研究采用PCBP4抗体进行RNA免疫沉淀(RIP)，证实PCBP4通过结合HBV RNA抑制病毒复制，为抗病毒机制提供了新见解。
注：以上文献为模拟示例，实际文献需通过PubMed或学术数据库检索确认。
The PCBP4 (poly(rC)-binding protein 4) antibody is a research tool used to study the function and expression of the PCBP4 protein, a member of the poly(C)-binding protein (PCBP) family. PCBPs are RNA-binding proteins involved in post-transcriptional regulation, including mRNA stability, splicing, and translation. PCBP4. also known as αCP4. contains three K-homology (KH) domains that mediate interactions with RNA or DNA. Unlike PCBP1-3. which are ubiquitously expressed and play roles in diverse cellular processes, PCBP4 is less characterized but has been implicated in tumor suppression. Studies suggest PCBP4 is induced by DNA damage or oncogenic stress and regulates pathways like TGF-β signaling and p53-mediated apoptosis, influencing cell cycle arrest or programmed cell death. Its dysregulation is linked to cancers, including lung, liver, and colorectal malignancies, where it may act as a tumor suppressor by inhibiting proliferation or metastasis.
The PCBP4 antibody enables detection and quantification of PCBP4 in techniques like Western blotting, immunoprecipitation, and immunohistochemistry. It aids in exploring PCBP4's subcellular localization, protein interactions, and expression patterns in normal versus diseased tissues. Research using this antibody has highlighted PCBP4's potential as a biomarker or therapeutic target in cancer. However, variability in antibody specificity and validation across studies underscores the need for rigorous controls. Ongoing research aims to clarify PCBP4's molecular mechanisms and translational relevance in human diseases.
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