| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RARC; NR1B3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human RARG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RARG抗体的3篇参考文献示例(内容为模拟，非真实文献)：
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1. **文献名称**：RARG Antibody Reveals a Novel Regulatory Network in Acute Myeloid Leukemia
**作者**：Smith A, et al.
**摘要**：研究利用RARG抗体通过ChIP-seq和免疫共沉淀技术，揭示了RARG在急性髓系白血病(AML)中通过调控特定靶基因(如HOXA9)影响细胞分化和化疗耐药性的机制。
2. **文献名称**：Prognostic Significance of RARG Protein Expression in Triple-Negative Breast Cancer
**作者**：Chen L, et al.
**摘要**：通过免疫组化(IHC)和Western blot分析，发现RARG抗体检测到的高表达水平与三阴性乳腺癌患者的不良预后显著相关，提示其作为潜在生物标志物的价值。
3. **文献名称**：RARG Antibody Identifies Chemotherapy Resistance Biomarkers in Colon Cancer
**作者**：Wang Y, et al.
**摘要**：研究使用RARG抗体筛选结肠癌细胞系，发现RARG通过激活Wnt/β-catenin通路促进奥沙利铂耐药，抗体阻断实验证实其可作为逆转耐药的潜在靶点。
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*注：以上文献为示例，实际引用需根据具体研究查阅真实数据库(如PubMed)。*
The retinoic acid receptor gamma (RARG) is a member of the nuclear receptor superfamily that regulates gene expression by binding retinoic acid, a derivative of vitamin A. It plays critical roles in cellular differentiation, proliferation, and apoptosis, particularly during embryonic development and tissue homeostasis. RARG is structurally similar to other retinoic acid receptors (RARα and RARβ) but exhibits distinct tissue-specific expression patterns, with high activity in the skin, brain, and certain immune cells.
Antibodies targeting RARG are essential tools in biomedical research, enabling the study of its expression, localization, and functional interactions. They are widely used in techniques like immunohistochemistry, Western blotting, and flow cytometry to investigate RARG's role in health and disease. Dysregulation of RARG has been implicated in cancers (e.g., leukemia, breast cancer), skin disorders, and developmental anomalies. For instance, RARG mutations or altered expression may contribute to chemotherapy resistance in cancer by affecting cell survival pathways.
In recent years, RARG antibodies have also gained attention in toxicology and drug development, as RARG is a key mediator of retinoid signaling and a potential biomarker for adverse drug reactions. Their specificity and reliability are critical for elucidating RARG-related molecular mechanisms and advancing therapeutic strategies targeting retinoid pathways.
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