| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RH; RHC; RHE; Rh4; RHPI; RhVI; RH30A; RHIXB; RhVIII; CD240CE; RhIVb(J) |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human RHCE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于RHCE抗体的参考文献示例(内容基于公开文献概括，非真实引用，仅作格式参考)：
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1. **文献名称**: *Molecular basis of RhCE antibody specificity in transfusion-related complications*
**作者**: Smith J, et al.
**摘要**: 研究通过基因测序和血清学分析，揭示了RHCE基因多态性与抗体产生的关联，探讨RHCE抗体在溶血性输血反应中的临床意义及分子机制。
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2. **文献名称**: *Clinical significance of anti-RhCE antibodies in autoimmune hemolytic anemia*
**作者**: Lee S, Patel R.
**摘要**: 分析了42例自身免疫性溶血性贫血患者血清中的RHCE抗体分布，发现其与疾病严重程度相关，并建议改进交叉配血策略以降低风险。
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3. **文献名称**: *RhCE antigen variants and their immunogenicity: A population-based study*
**作者**: González A, et al.
**摘要**: 通过对全球不同人群的RhCE抗原频率研究，揭示了特定变异体(如ceS等)更易诱发抗体生成，为精准输血提供数据支持。
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注：以上为模拟文献，如需真实文献，建议检索PubMed或学术数据库(关键词：RHCE antibody, Rh blood group, transfusion)。
**Background of RHCE Antibodies**
The RHCE antibody is associated with the Rh blood group system, a critical component in transfusion medicine and hemolytic disease of the fetus and newborn (HDFN). The Rh system comprises over 50 antigens, primarily encoded by the *RHD* and *RHCE* genes. The *RHCE* gene produces the Ce, ce, cE, and CE antigens (collectively RhCE), which, alongside RhD, form the basis of Rh antigen expression.
RHCE antibodies typically arise through alloimmunization, such as after incompatible blood transfusions, pregnancy, or organ transplantation. These antibodies target specific RhCE antigens (e.g., anti-C, anti-c, anti-E, anti-e) and can cause hemolytic transfusion reactions or HDFN. Clinically, anti-c and anti-E are among the most common non-D Rh antibodies. Their prevalence varies by ethnicity, reflecting differences in Rh antigen distribution across populations.
Unlike RhD antibodies, which are aggressively managed due to their strong immunogenicity, RHCE antibodies are less frequently implicated in severe complications but remain significant in prenatal care and transfusion protocols. Testing for RHCE antibodies involves serological methods (e.g., indirect antiglobulin test) and molecular genotyping in complex cases. Challenges include antigenic variability and the risk of anamnestic responses in subsequent exposures.
Research continues to refine risk stratification and prophylactic strategies, particularly for high-risk groups. Understanding RHCE antibody dynamics is essential for ensuring safe transfusion practices and mitigating adverse outcomes in sensitized individuals.
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