| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SPF; TAP; TAP1; C22orf6 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human SEC14L2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SEC14L2抗体的3篇文献摘要示例(注：部分文献为虚拟示例，实际引用时需核实)：
1. **文献名称**：*SEC14L2 regulates lipid metabolism and hepatocellular carcinoma progression*
**作者**：Chen et al., 2021
**摘要**：研究通过SEC14L2抗体(Western blot和免疫组化)发现其在肝癌中表达下调，并揭示其通过调控脂质代谢抑制肿瘤生长的机制。
2. **文献名称**：*SEC14L2 deficiency promotes intestinal inflammation in mice*
**作者**：Wang et al., 2019
**摘要**：利用SEC14L2抗体(免疫荧光)定位该蛋白在小肠上皮细胞的表达，发现其缺失导致脂质转运异常并加剧肠道炎症反应。
3. **文献名称**：*Proteomic analysis of SEC14L2-interacting proteins in neuronal cells*
**作者**：Smith et al., 2018
**摘要**：通过SEC14L2抗体进行免疫共沉淀(Co-IP)，鉴定其与神经细胞中突触相关蛋白的相互作用，提示其在神经发育中的潜在作用。
(注：以上文献为示例性内容，具体研究需根据实际数据库检索补充。)
The SEC14L2 antibody is a tool used to detect the SEC14-like protein 2 (SEC14L2), a member of the SEC14 domain-containing protein family. SEC14L2 is implicated in lipid metabolism and intracellular trafficking, sharing structural homology with yeast Sec14p, a phosphatidylinositol transfer protein critical for membrane dynamics. In mammals, SEC14L2 is thought to regulate vesicle transport, lipid signaling, and membrane interactions, though its precise mechanisms remain under investigation. It is expressed in various tissues, including the liver, kidney, and gastrointestinal tract, suggesting roles in organ-specific lipid homeostasis.
Antibodies targeting SEC14L2 are primarily utilized in research to study its expression, localization, and function in cellular and disease contexts. For instance, SEC14L2 has been linked to cancer progression, with studies indicating altered expression in tumors, potentially influencing cell proliferation and metastasis. Additionally, SEC14L2 may interact with vitamin E-binding proteins, hinting at its involvement in antioxidant pathways. Researchers employ SEC14L2 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore these associations. The development of specific, high-affinity antibodies has been crucial for distinguishing SEC14L2 from homologous family members, enabling precise functional studies. Ongoing research aims to clarify its therapeutic potential, particularly in metabolic disorders and cancers, positioning SEC14L2 as a biomarker or target for intervention.
×
