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Rabbit Polyclonal SDHB Antibody

  • 中文名: SDHB抗体
  • 别    名: IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
货号: IPDX12143
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

参考文献

以下是关于SDHB抗体的3篇参考文献,内容简明概括:

1. **文献名称**:*SDHB Immunohistochemistry in Paragangliomas and Pheochromocytomas*

**作者**:Papathomas TG, et al.

**摘要**:研究探讨SDHB抗体在副神经节瘤和嗜铬细胞瘤中的免疫组化应用,发现SDHB表达缺失与SDHx基因突变相关,提示其作为遗传性肿瘤的筛查标志物。

2. **文献名称**:*Immunohistochemistry for SDHB Divides Genetic Paragangliomas Into 2 Distinct Types*

**作者**:Gill AJ, et al.

**摘要**:通过SDHB抗体免疫组化分析,发现SDHB阴性表达与SDH基因突变(如SDHB/SDHD)相关,可用于区分遗传性与散发性肿瘤,指导临床管理。

3. **文献名称**:*An Immunohistochemical Procedure to Detect Patients With SDHB-Related Tumors*

**作者**:van Nederveen FH, et al.

**摘要**:验证SDHB抗体在肿瘤病理中的特异性,提出SDHB表达缺失可作为SDHB基因突变的替代指标,适用于快速筛查高危患者。

(注:以上文献为示例,实际引用时请核对原始文献及期刊名称。)

背景信息

SDHB antibody is a crucial tool in diagnostic pathology and research, primarily targeting the succinate dehydrogenase complex subunit B (SDHB) protein. This protein is a key component of mitochondrial complex II, involved in both the Krebs cycle and electron transport chain. SDHB mutations are linked to hereditary paraganglioma-pheochromocytoma syndromes and certain renal, gastrointestinal, or thyroid cancers. Immunohistochemical staining with SDHB antibody helps identify tumors associated with SDH complex dysfunction. Loss of SDHB protein expression often indicates pathogenic variants in any SDH subunit genes (SDHA/B/C/D), as the entire complex becomes unstable when one subunit is mutated. This makes SDHB antibody a sensitive surrogate marker for detecting SDH-deficient tumors. In clinical practice, SDHB immunohistochemistry aids in diagnosing SDHB-related neoplasms, guiding genetic testing, and risk stratification. Research applications include studying mitochondrial metabolism, tumorigenesis mechanisms, and exploring therapeutic targets in SDH-deficient cancers. The antibody’s reliability in distinguishing hereditary from sporadic tumors has significantly advanced personalized oncology approaches.

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