| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DEAR1 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TRIM62 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRIM62抗体的参考文献示例(注：部分信息为模拟示例，仅供参考)：
1. **文献名称**: "TRIM62 Acts as a Tumor Suppressor in Colorectal Cancer by Promoting β-Catenin Ubiquitination"
**作者**: Li, X. et al.
**摘要**: 该研究利用TRIM62抗体进行Western blot和免疫组化分析，发现TRIM62通过泛素化降解β-catenin抑制结直肠癌进展，低表达TRIM62与患者预后不良相关。
2. **文献名称**: "TRIM62 Regulates Antiviral Innate Immunity through Interaction with MAVS"
**作者**: Zhang, Y. et al.
**摘要**: 研究通过TRIM62抗体介导的免疫共沉淀实验，揭示TRIM62与线粒体抗病毒信号蛋白(MAVS)相互作用，增强Ⅰ型干扰素通路，从而抑制RNA病毒复制。
3. **文献名称**: "TRIM62 as a Biomarker in Triple-Negative Breast Cancer: Implications for Immune Microenvironment Modulation"
**作者**: Wang, H. et al.
**摘要**: 使用TRIM62抗体进行组织芯片分析，发现TRIM62高表达与肿瘤浸润淋巴细胞增加相关，提示其可能通过调节免疫微环境抑制乳腺癌转移。
4. **文献名称**: "TRIM62 Promotes Ubiquitination of EGFR to Suppress Lung Adenocarcinoma Progression"
**作者**: Chen, L. et al.
**摘要**: 通过TRIM62抗体检测肺癌细胞系中的蛋白表达水平，发现TRIM62通过泛素化降解EGFR抑制肺癌增殖，其缺失可导致EGFR信号通路异常激活。
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**注**：以上文献为示例性质，具体内容建议通过PubMed、Web of Science等数据库以“TRIM62 antibody”或“TRIM62 function”为关键词检索真实文献。
TRIM62 (Tripartite Motif-Containing Protein 62) is a member of the TRIM protein family, characterized by conserved RING, B-box, and coiled-coil domains. It functions as an E3 ubiquitin ligase, participating in protein ubiquitination and degradation via the proteasome system. TRIM62 plays roles in cell proliferation, differentiation, apoptosis, and innate immunity. Research links it to cancer pathogenesis, where it may act as a tumor suppressor or oncogene depending on context. For instance, TRIM62 downregulation is observed in certain cancers (e.g., breast, lung), correlating with poor prognosis, while its overexpression in others (e.g., liver cancer) may promote tumor progression.
TRIM62 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to quantify protein levels in tissues or cell lines. Both polyclonal and monoclonal antibodies are available, with validation steps (e.g., knockout controls) critical to ensure specificity. These antibodies aid in exploring TRIM62’s regulatory mechanisms, such as its involvement in NF-κB or Wnt signaling pathways, and its potential as a therapeutic target. Recent studies also investigate its role in viral immunity and inflammatory diseases, highlighting its broad biological relevance.
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