| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SERTA domain-containing protein 4, SERTAD4 |
| Entrez GeneID | 56256 |
| WB Predicted band size | 39.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SERTAD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-293 amino acids from the C-terminal region of human SERTAD4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SERTAD4抗体的3篇参考文献的简要信息(注：文献为虚构示例，实际文献需通过数据库检索确认)：
1. **文献名称**: "SERTAD4 regulates cell cycle progression through E2F1 modulation in colorectal cancer"
**作者**: Li X, et al.
**摘要**: 本研究利用SERTAD4特异性抗体进行免疫沉淀和Western blot分析，发现SERTAD4通过结合并抑制E2F1转录因子活性，延缓结直肠癌细胞G1/S期转换，提示其作为肿瘤抑制因子的潜在作用。
2. **文献名称**: "Development and validation of a novel anti-SERTAD4 monoclonal antibody for immunohistochemical applications"
**作者**: Gupta R, et al.
**摘要**: 文章报道了一种高特异性抗SERTAD4单克隆抗体的开发，验证了其在人组织切片中的免疫组化适用性，并发现SERTAD4在乳腺癌组织中表达上调，与患者预后不良相关。
3. **文献名称**: "SERTAD4 interacts with CBP/p300 to modulate transcriptional co-activation in hepatocellular carcinoma"
**作者**: Wang Y, et al.
**摘要**: 通过免疫共沉淀(使用SERTAD4抗体)和荧光素酶报告基因实验，揭示了SERTAD4作为转录共激活因子与CBP/p300复合物协同作用，促进肝癌细胞中促增殖基因的表达。
如需真实文献，建议在PubMed或Web of Science中检索关键词“SERTAD4 antibody”或“SERTAD4 function”。
The SERTAD4 antibody is a research tool designed to detect and study SERTAD4 (SERTA domain-containing 4), a protein belonging to the SERTA domain-containing family. SERTAD4 is implicated in transcriptional regulation and cell cycle control, though its precise biological functions remain less characterized compared to other family members like SERTAD1 or SERTAD3. Structurally, SERTAD4 contains a conserved SERTA domain, which may facilitate protein-protein interactions or modulate transcriptional activity. Emerging studies suggest its involvement in cancer progression, with overexpression observed in certain malignancies, such as breast and colorectal cancers, potentially linked to oncogenic signaling pathways.
The SERTAD4 antibody is primarily used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions in cellular or tissue samples. Researchers employ it to explore SERTAD4's role in tumorigenesis, therapeutic resistance, or as a biomarker. However, limited data on its binding specificity, isoforms, and cross-reactivity with homologous proteins (e.g., SERTAD2) necessitate careful validation in experimental settings. Current research aims to clarify its mechanistic contributions to diseases and evaluate its utility as a diagnostic or therapeutic target. Further studies are required to define its regulatory networks and physiological contexts.
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