| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | WAP four-disulfide core domain protein 12, Putative protease inhibitor WAP12, Whey acidic protein 2, WFDC12, C20orf122, WAP2 |
| Entrez GeneID | 128488 |
| WB Predicted band size | 12.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This WFDC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human WFDC12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于WFDC12抗体的3篇模拟参考文献示例(非真实文献，仅作格式参考)：
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1. **文献名称**: *WFDC12 as a novel biomarker in prostate cancer: Development of a polyclonal antibody for detection*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化开发了一种针对WFDC12的多克隆抗体，发现WFDC12在前列腺癌组织中显著高表达，且与肿瘤侵袭性相关。该抗体可作为潜在的诊断工具及治疗靶点研究的基础。
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2. **文献名称**: *WFDC12 antibody-based analysis reveals its role in modulating inflammatory response*
**作者**: Chen L, et al.
**摘要**: 利用特异性WFDC12抗体，研究者发现WFDC12通过抑制中性粒细胞弹性蛋白酶活性参与炎症调控。实验表明，阻断WFDC12可能加剧炎症反应，提示其具有免疫调节功能。
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3. **文献名称**: *Therapeutic potential of anti-WFDC12 monoclonal antibody in ovarian cancer*
**作者**: Gupta R, et al.
**摘要**: 通过构建靶向WFDC12的单克隆抗体，本研究证实其在卵巢癌细胞系中可诱导凋亡并抑制转移。动物模型显示抗体治疗显著延长生存期，提示其临床转化潜力。
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**注**：以上文献及内容均为虚拟示例，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文。如需进一步协助文献检索，请提供更多背景信息。
The WFDC12 (WAP four-disulfide core domain 12) antibody is a research tool designed to target the WFDC12 protein, a member of the WAP-type protease inhibitor family. WFDC12. also known as SWAM2 or eppin-like protein, is encoded by the WFDC12 gene located on human chromosome 20q13.12. This secreted protein contains a characteristic WAP domain, which typically mediates protease inhibitory activity, suggesting potential roles in regulating proteolytic processes in extracellular environments.
WFDC12 is predominantly expressed in reproductive tissues (e.g., testes, epididymis) and certain epithelial cells, implicating its involvement in male fertility, antimicrobial defense, or mucosal immunity. Studies also link WFDC12 to cancer progression, with overexpression observed in malignancies like prostate and ovarian cancers, where it may influence cell proliferation, invasion, or immune evasion.
Antibodies against WFDC12 are utilized to investigate its expression patterns, molecular interactions, and functional mechanisms. They enable applications such as immunohistochemistry, Western blotting, and ELISA, aiding in biomarker discovery for diagnostic or prognostic purposes. Recent research explores WFDC12’s dual role as a protease inhibitor and immunomodulator, highlighting its therapeutic potential in cancer and inflammatory diseases. However, its precise physiological and pathological functions remain under investigation, necessitating further validation of WFDC12 antibodies for specificity and reliability in diverse experimental models.
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