Rabbit Polyclonal PQLC2 Antibody

The PQLC2 antibody is designed to target the PQLC2 protein, a lysosomal cationic amino acid transporter belonging to the PQ-loop repeat family. Identified as a critical player in cellular metabolism, PQLC2 (also known as SLC66A1) facilitates the transport of arginine, lysine, and other cationic amino acids across lysosomal membranes, maintaining amino acid homeostasis essential for processes like mTOR signaling, autophagy, and nutrient sensing. Dysregulation of PQLC2 has been linked to lysosomal storage disorders, neurodegenerative diseases, and cancer, where altered lysosomal function disrupts cellular clearance or growth pathways. Research into PQLC2 gained momentum following its association with the conserved Vacuolar Protein Sorting-associated Protein (VPS) network, which regulates endolysosomal trafficking. Antibodies against PQLC2 are widely used in Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interaction partners in disease models. Recent studies also explore its role in modulating chemotherapy resistance in cancers, as lysosomal amino acid efflux influences cell survival under stress. The development of PQLC2-specific antibodies has thus become pivotal in elucidating lysosomal biology and identifying therapeutic targets for lysosome-related pathologies.