| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Amyloid protein homolog ; Amyloid-like protein 2 precursor; APP2; APPH; CDEI-box binding protein |
| Entrez GeneID | 334; |
| WB Predicted band size | 86kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 755 (P-T-Y(p)-K-Y) derived from Human APLP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于APLP2 (Phospho-Tyr755)抗体的3篇参考文献，包含文献名称、作者及简要摘要内容：
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1. **文献名称**：*Phosphorylation of amyloid precursor-like protein 2 (APLP2) regulates synaptic adhesion and neuronal morphology*
**作者**：Klevanski M, et al.
**摘要**：该研究揭示了APLP2在Tyr755位点的磷酸化对其在突触黏附和神经元形态调节中的作用。通过特异性抗体验证，发现磷酸化修饰影响APLP2与细胞骨架蛋白的相互作用，进而调控突触可塑性。
2. **文献名称**：*Tyrosine phosphorylation of APLP2 modulates its interaction with ShcA adaptor protein in neuronal signaling*
**作者**：Saito Y, et al.
**摘要**：研究利用Phospho-Tyr755抗体证明APLP2的磷酸化促进其与ShcA适配蛋白的结合，激活下游MAPK信号通路，暗示其在神经元存活和分化中的潜在功能。
3. **文献名称**：*Characterization of a phospho-specific antibody for APLP2 Tyr755 and its application in Alzheimer's disease models*
**作者**：Wang H, et al.
**摘要**：该文献报道了一种针对APLP2 Tyr755磷酸化位点的抗体的开发与验证，并应用于阿尔茨海默病模型中，发现该位点磷酸化水平与淀粉样斑块沉积呈负相关。
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以上文献可通过PubMed或Google Scholar检索标题及作者进一步获取全文。若需更多信息，可结合关键词“APLP2 phosphorylation Tyr755”或相关信号通路(如ShcA/MAPK)深入查询。
The amyloid precursor-like protein 2 (APLP2) is a member of the amyloid precursor protein (APP) family, sharing structural and functional similarities with APP, which is best known for its role in Alzheimer’s disease. APLP2 is a transmembrane glycoprotein involved in synaptic plasticity, cell adhesion, and neuronal development. Phosphorylation at specific tyrosine residues, such as Tyr755. regulates its interactions with signaling adaptors (e.g., Shc proteins) and modulates downstream pathways, including those linked to cell growth, survival, and differentiation. The phosphorylation of Tyr755 is implicated in post-translational modifications that influence APLP2’s role in cellular signaling networks.
The APLP2 (Phospho-Tyr755) antibody is a specialized tool designed to detect APLP2 when phosphorylated at Tyr755. It is commonly used in techniques like Western blotting, immunoprecipitation, or immunofluorescence to study APLP2 activation, trafficking, or its interaction partners in physiological or disease contexts. Research involving this antibody often focuses on neurodegenerative diseases, cancer, or developmental biology, where dysregulated phosphorylation of APLP2 may contribute to pathological mechanisms. Validating the antibody’s specificity via knockout controls or peptide competition is critical to ensure accurate detection of this post-translationally modified form.
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