Rabbit Polyclonal HP1α(Phospho-Ser92) Antibody

The HP1α (Phospho-Ser92) antibody is a specialized tool used to study post-translational modifications of Heterochromatin Protein 1 alpha (HP1α), a key regulator of chromatin structure and gene silencing. HP1α, encoded by the CBX5 gene, binds to trimethylated histone H3 lysine 9 (H3K9me3) via its chromodomain, facilitating heterochromatin formation and epigenetic regulation. Phosphorylation at serine 92 (Ser92) modulates HP1α's functional dynamics, influencing its interactions with chromatin or partner proteins during processes like DNA repair, cell cycle progression, or transcriptional repression. This antibody specifically detects HP1α when phosphorylated at Ser92. enabling researchers to investigate its phosphorylation status under various cellular conditions (e.g., stress responses, differentiation, or oncogenic signaling). It is widely used in techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP) to map spatial-temporal phosphorylation patterns. Studies leveraging this antibody have contributed to understanding HP1α's role in maintaining genomic stability, epigenetic memory, and its dysregulation in diseases like cancer. Validation typically includes knockout controls or phosphatase treatment to confirm specificity. Its applications span cancer biology, epigenetics, and chromatin dynamics research.