| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAV2; Caveolin-2; |
| Entrez GeneID | 858; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 27 (L-E-Y(p)-A-D) derived from Human Caveolin 2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **Caveolin 2 (Phospho-Tyr27) 抗体** 的参考文献及其简要摘要：
1. **"Role of caveolin-2 tyrosine phosphorylation in insulin signaling"**
- **作者**: Sanguinetti AR, Mastick CC
- **摘要**: 该研究探讨了Caveolin-2在酪氨酸27位点(Tyr27)的磷酸化在胰岛素受体信号传导中的作用，通过Phospho-Tyr27抗体验证了其在脂肪细胞中与胰岛素诱导的葡萄糖摄取相关。
2. **"Phosphorylation of caveolin-2 on Tyr27 promotes cell migration and invasion"**
- **作者**: Lee H, Park DS
- **摘要**: 文章发现Caveolin-2的Tyr27磷酸化通过激活Rho GTPase信号通路增强癌细胞迁移和侵袭能力，使用特异性抗体证实了磷酸化位点的功能。
3. **"Caveolin-2 phosphorylation regulates its interaction with actin cytoskeleton"**
- **作者**: Toya Y, Ikezu T
- **摘要**: 该研究揭示了Caveolin-2的Tyr27磷酸化调控其与肌动蛋白骨架的结合，影响细胞形态和运动，Phospho-Tyr27抗体被用于免疫荧光定位分析。
4. **"Post-translational modifications of caveolins in endothelial dysfunction"**
- **作者**: Mora-Coral C, Briones AM
- **摘要**: 综述总结了Caveolin-2的翻译后修饰(包括Tyr27磷酸化)在内皮细胞功能失调中的病理意义，相关抗体被用于验证氧化应激模型中的修饰水平。
这些文献涵盖了Caveolin-2 Tyr27磷酸化在信号传导、细胞迁移及疾病中的机制研究，均涉及该特异性抗体的实验应用。实际引用前建议核对文献来源的准确性。
Caveolin 2 (Phospho-Tyr27) antibody is a specialized tool used to study the phosphorylation state of Caveolin-2 at tyrosine residue 27. a post-translational modification implicated in cellular signaling and membrane dynamics. Caveolin-2 is a member of the caveolin family, which includes structurally related proteins (Caveolin-1. -2. -3) that form oligomeric complexes to shape caveolae, invaginated lipid raft domains in the plasma membrane. These domains regulate membrane trafficking, signal transduction, and cholesterol homeostasis.
Phosphorylation of Caveolin-2 at Tyr27 is linked to Src kinase activity, which modulates interactions with signaling partners and caveolae organization. This modification may influence cellular processes like endocytosis, mechanoprotection, and stress responses. The antibody specifically detects the phosphorylated form, enabling researchers to investigate dynamic changes in Caveolin-2 activation under conditions such as oxidative stress, growth factor stimulation, or pathological states (e.g., cancer, cardiovascular diseases).
Validation typically includes Western blotting, immunofluorescence, or immunoprecipitation using cell lysates or tissues. Its application helps elucidate mechanisms of caveolae-mediated signaling and membrane remodeling. Studies using this antibody contribute to understanding how tyrosine phosphorylation fine-tunes Caveolin-2's role in cellular adaptation and disease progression. Proper controls (e.g., phosphorylation inhibitors, knockout samples) are essential to confirm specificity.
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