Rabbit Polyclonal HDAC6(Phospho-Ser22) Antibody

The HDAC6 (Phospho-Ser22) antibody is a specialized tool used to detect the phosphorylation status of histone deacetylase 6 (HDAC6) at serine residue 22. HDAC6. a class IIb deacetylase, is unique among histone deacetylases due to its cytoplasmic localization and dual catalytic domains, which primarily target non-histone substrates like α-tubulin, HSP90. and cortactin. It regulates critical cellular processes including protein degradation, cytoskeletal dynamics, and stress response. Phosphorylation at Ser22 is a post-translational modification implicated in modulating HDAC6 activity, substrate interaction, or subcellular trafficking. Studies suggest this modification may influence HDAC6's role in cellular pathways such as autophagy, mitotic progression, or viral infection. The HDAC6 (Phospho-Ser22) antibody enables researchers to investigate this regulatory mechanism through techniques like Western blotting, immunofluorescence, or immunoprecipitation. Its applications span cancer research (e.g., metastasis, drug resistance), neurodegenerative diseases (e.g., tauopathies), and immune regulation. Validation of this antibody typically includes testing in phosphorylation-deficient cell models or using phosphatase treatment to confirm signal specificity. Understanding Ser22 phosphorylation dynamics provides insights into HDAC6-related disease mechanisms and potential therapeutic targeting.