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Rabbit Polyclonal PDLIM5(Phospho-Tyr251) Antibody

  • 中文名： PDLIM5 (Phospho-Tyr251)抗体
  • 别    名： PDLIM5; ENH; L9; PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein
货号: IPDX40812
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesPDLIM5; ENH; L9; PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein
Entrez GeneID10611;
WB Predicted band size64kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from human PDLIM5 around the phosphorylation site of Y251.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是假设的示例参考文献(仅供格式参考，实际文献需通过学术数据库查询)：

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1. **文献名称**: "PDLIM5 tyrosine phosphorylation regulates cardiac myocyte hypertrophy signaling"

**作者**: Zhang et al.

**摘要**: 研究报道PDLIM5在Tyr251位点的磷酸化通过激活MAPK通路促进心肌细胞肥大，使用Phospho-Tyr251特异性抗体验证了其在病理条件下的表达上调及功能机制。

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2. **文献名称**: "Role of PDLIM5 phosphotyrosine in neuronal synaptic plasticity"

**作者**: Thompson & Lee

**摘要**: 通过Phospho-Tyr251抗体进行免疫沉淀和免疫荧光实验，发现PDLIM5磷酸化水平影响突触蛋白稳定性，调控海马神经元的长时程增强(LTP)过程。

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3. **文献名称**: "PDLIM5 as a biomarker in cancer: Phosphorylation-dependent interactions"

**作者**: Gupta et al.

**摘要**: 研究利用Phospho-Tyr251抗体分析乳腺癌组织样本，揭示PDLIM5磷酸化与EGFR信号通路的关联性，提示其作为潜在治疗靶点的可能性。

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4. **文献名称**: "Structural basis of PDLIM5 tyrosine phosphorylation in cytoskeletal remodeling"

**作者**: Watanabe et al.

**摘要**: 结合X射线晶体学和Phospho-Tyr251抗体的功能实验，阐明Tyr251磷酸化如何改变PDLIM5构象，进而调控细胞骨架重排和迁移能力。

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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“PDLIM5 Tyr251 phosphorylation antibody”检索。建议结合抗体生产商(如CST、Abcam)提供的产品引用文献进一步筛选。

背景信息

The PDLIM5 (Phospho-Tyr251) antibody is designed to detect the phosphorylated form of PDLIM5 (PDZ and LIM domain-containing protein 5) at tyrosine residue 251. PDLIM5. also known as ENH, is a scaffolding protein involved in cytoskeletal organization, signal transduction, and cellular stress responses. It contains a PDZ domain for protein-protein interactions and LIM domains that mediate binding to kinases, transcription factors, and structural proteins. Phosphorylation at Tyr251 is critical for regulating PDLIM5's functional interactions, particularly in pathways like cardiac hypertrophy, neuronal development, and cancer progression. This post-translational modification may influence its ability to recruit signaling molecules, modulate actin dynamics, or shuttle between cellular compartments. The antibody serves as a tool to study PDLIM5 activation in diseases such as heart failure, psychiatric disorders, or malignancies, where dysregulated phosphorylation has been implicated. Researchers utilize it in techniques like Western blotting, immunofluorescence, or immunoprecipitation to explore phosphorylation-dependent mechanisms in cell models or tissue samples. Its specificity for the phosphorylated epitope helps dissect PDLIM5's role in cellular signaling networks and disease pathophysiology.

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