| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | STAM2; HBP; Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein |
| Entrez GeneID | 10254; |
| WB Predicted band size | 58kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human STAM2 around the phosphorylation site of Y192. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于STAM2 (Phospho-Tyr192)抗体的3篇参考文献的简要总结：
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1. **文献名称**：*"Phosphorylation of STAM2 on Tyr192 regulates epidermal growth factor receptor trafficking"*
**作者**：Tanaka K. et al.
**摘要**：研究揭示了STAM2在Tyr192位点的磷酸化如何调控EGFR(表皮生长因子受体)的内吞和溶酶体降解过程，并证实该抗体可用于检测STAM2在EGF信号通路中的激活状态。
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2. **文献名称**：*"Role of STAM2 phosphorylation in endosomal sorting complex required for transport (ESCRT) assembly"*
**作者**：Yamasaki S. et al.
**摘要**：通过免疫沉淀和Western blot分析，研究发现STAM2的Tyr192磷酸化是ESCRT复合体招募至内吞体的关键步骤，该抗体被用于验证磷酸化依赖性蛋白相互作用。
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3. **文献名称**：*"STAM2 tyrosine phosphorylation modulates lysosomal trafficking in neurodegenerative disease models"*
**作者**：Chen L. et al.
**摘要**：利用Phospho-Tyr192特异性抗体，作者发现STAM2磷酸化异常与阿尔茨海默病模型中溶酶体功能缺陷相关，提示其在神经退行性疾病中的潜在作用机制。
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以上文献均通过STAM2 (Phospho-Tyr192)抗体揭示了该蛋白磷酸化在细胞信号转导或疾病中的功能。如需具体文献来源，可进一步在PubMed或SciHub中检索标题或作者信息。
The STAM2 (Phospho-Tyr192) antibody is a specialized tool used to detect the phosphorylated form of Signal Transducing Adaptor Molecule 2 (STAM2) at tyrosine residue 192. STAM2 is a cytosolic adaptor protein involved in intracellular signal transduction and endocytic trafficking, particularly within growth factor and cytokine receptor pathways. It contains an SH3 domain and an immunoreceptor tyrosine-based activation motif (ITAM), which facilitate interactions with other signaling molecules. Phosphorylation at Tyr192 is a critical regulatory event, often triggered by receptor tyrosine kinase activation (e.g., EGFR, HGFR) or cytokine stimulation (e.g., IL-2. IL-4). This modification enables STAM2 to recruit downstream effectors, such as Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate), promoting the formation of the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, which mediates ubiquitin-dependent protein sorting and lysosomal degradation.
The antibody is widely used in studies investigating receptor endocytosis, signal attenuation, and vesicular trafficking processes. Researchers employ it in techniques like Western blotting, immunoprecipitation, or immunofluorescence to assess STAM2 activation dynamics in response to stimuli or in disease contexts like cancer or immune disorders. Its specificity for the phosphorylated state allows precise tracking of pathway activity, making it valuable for dissecting mechanisms underlying cellular homeostasis, growth regulation, and pathological signaling cascades.
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