| WB | 咨询技术 | Human,Mouse,Rat Monkey |
| IF | 咨询技术 | Human,Mouse,Rat Monkey |
| IHC | 1/100-1/300 | Human,Mouse,Rat Monkey |
| ICC | 技术咨询 | Human,Mouse,Rat Monkey |
| FCM | 咨询技术 | Human,Mouse,Rat Monkey |
| Elisa | 1/40000 | Human,Mouse,Rat Monkey |
| Aliases | GABRB1; Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1 |
| Entrez GeneID | 2560; |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat Monkey |
| Immunogen | Synthesized peptide derived from human GABAA Rβ1 around the phosphorylation site of S434. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于GABAA Rβ1 (Phospho-Ser434)抗体的模拟参考文献(注：以下内容为示例，非真实文献)：
1. **"Phosphorylation of GABAA Receptor β1 Subunit at Ser434 Regulates Synaptic Inhibition"**
- **作者**: Smith A, et al.
- **摘要**: 本研究揭示了GABAA受体β1亚基Ser434位点的磷酸化对突触抑制功能的调控作用，利用特异性抗体证实该位点的磷酸化可增强受体介导的电流，并影响神经元网络兴奋性。
2. **"Development and Validation of a Phospho-Specific Antibody for GABAA Rβ1 (Ser434) in Neurodegenerative Models"**
- **作者**: Chen L, et al.
- **摘要**: 文章描述了针对GABAA Rβ1 (Phospho-Ser434)抗体的制备与验证，证明其在阿尔茨海默病模型小鼠脑组织中的特异性检测能力，并发现该位点磷酸化水平与突触功能损伤相关。
3. **"Kinase-Dependent Modulation of GABAA Receptors via β1-Ser434 Phosphorylation"**
- **作者**: Park J, et al.
- **摘要**: 通过Phospho-Ser434抗体研究发现，蛋白激酶C(PKC)介导的β1亚基磷酸化可调节GABAA受体内吞过程，进而影响焦虑相关行为中的抑制性神经传递。
4. **"Phosphorylation Status of GABAA Rβ1 Ser434 in Epileptogenesis: Insights from a Targeted Antibody Approach"**
- **作者**: Rossi M, et al.
- **摘要**: 利用特异性抗体分析癫痫模型大鼠脑组织，发现Ser434磷酸化水平在癫痫发作后显著升高，提示该位点可能成为抗癫痫药物开发的新靶点。
建议通过PubMed或Google Scholar搜索真实文献时使用关键词：**GABAA receptor beta1 subunit phosphorylation Ser434 antibody**。
The GABAA receptor β1 subunit (GABAA Rβ1) is a critical component of GABA type A receptors, which are ligand-gated chloride channels mediating fast inhibitory neurotransmission in the central nervous system. Phosphorylation of specific residues, such as serine 434 (Ser434), plays a key role in regulating receptor function, trafficking, and synaptic plasticity. The GABAA Rβ1 (Phospho-Ser434) antibody is a specialized tool designed to detect the phosphorylated state of Ser434 within the β1 subunit. This post-translational modification is implicated in modulating receptor activity in response to neurotransmitters, drugs, or cellular signaling pathways.
Research using this antibody helps elucidate mechanisms underlying GABAergic signaling, including how phosphorylation events fine-tune inhibitory synaptic strength. It is widely employed in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study receptor localization, expression patterns, and activity-dependent changes in neurological or psychiatric disorders, such as epilepsy, anxiety, and addiction. The antibody’s specificity for the phosphorylated Ser434 residue enables investigations into kinase/phosphatase pathways (e.g., PKC, PKA) that dynamically regulate GABAA receptor function.
Understanding GABAA Rβ1 phosphorylation at Ser434 provides insights into synaptic adaptation, pharmacotherapy targets, and disease mechanisms linked to inhibitory signaling dysregulation.
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