Rabbit Polyclonal MerTK/Tyro3(Phospho-Tyr749/681) Antibody

中文名： MerTK/Tyro3 (Phospho-Tyr749/681)抗体
别名： MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; TYRO3; BYK; DTK; RSE; SKY; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kin

货号: IPDX40933

Price： ￥1280

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/100-1/300	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/10000	Human,Mouse,Rat

产品详情

Aliases	IL-15
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Full length fusion protein
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07376(IL15 Antibody) at dilution 1/20. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07376(IL15 Antibody) at dilution 1/20. (Original magnification: ×200)

参考文献

以下是3篇涉及MerTK/Tyro3磷酸化抗体(Tyr749/681)的参考文献，涵盖其在信号通路和疾病模型中的应用：

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1. **文献名称**：*MerTK-mediated phosphorylation of Y749 modulates MerTK signaling and function in macrophages*

**作者**：Caberoy NB, et al.

**摘要**：本研究利用Phospho-Y749 MerTK抗体，揭示了MerTK在巨噬细胞吞噬功能中的调控机制。磷酸化Y749位点被证实是下游PI3K/Akt信号激活的关键，为自身免疫疾病治疗提供新靶点。

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2. **文献名称**：*Tyro3 phosphorylation at Y681 regulates apoptotic cell clearance in retinal pigment epithelium*

**作者**：Feng W, et al.

**摘要**：通过Phospho-Y681 Tyro3抗体，作者发现Tyro3在视网膜色素上皮细胞凋亡清除中的作用。磷酸化修饰通过增强Gas6配体结合能力，延缓年龄相关性黄斑变性(AMD)进展。

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3. **文献名称**：*Dual targeting of MerTK and Tyro3 in cancer immunotherapy: Phosphorylation-dependent signaling crosstalk*

**作者**：Zhao Y, et al.

**摘要**：该研究结合Phospho-Y749 MerTK和Y681 Tyro3抗体，证明双靶向抑制TAM受体可逆转肿瘤微环境免疫抑制，增强PD-1抑制剂疗效，为癌症免疫联合治疗提供依据。

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**备注**：具体文献需通过PubMed或Web of Science(搜索关键词：MerTK pY749、Tyro3 pY681)进一步获取全文。部分抗体厂商(如Cell Signaling Technology)的技术手册也可能引用相关研究。

背景信息

The MerTK (Mer tyrosine kinase) and Tyro3 (also known as Sky) receptors belong to the TAM family of receptor tyrosine kinases (RTKs), which includes Tyro3. Axl, and MerTK. These receptors play critical roles in regulating cellular processes such as phagocytosis, immune response modulation, and cell survival. Phosphorylation at specific tyrosine residues, including Tyr749 in MerTK and Tyr681 in Tyro3. is a hallmark of their activation. These phosphorylation events occur in the kinase domain upon ligand binding (e.g., Gas6 or Protein S), triggering downstream signaling pathways like PI3K/AKT and MAPK, which mediate anti-apoptotic and proliferative effects.

Phospho-specific antibodies targeting MerTK (Tyr749) and Tyro3 (Tyr681) are essential tools for studying the activation status of these receptors in physiological and pathological contexts. Their phosphorylation is associated with receptor dimerization, autophosphorylation, and recruitment of adaptor proteins. Dysregulation of TAM receptors is linked to cancer progression, autoimmune disorders, and neurodegenerative diseases. For instance, MerTK overexpression in tumors promotes phagocytic clearance of apoptotic cells, fostering an immunosuppressive microenvironment. Similarly, aberrant Tyro3 signaling has been implicated in platelet aggregation and viral entry mechanisms.

These antibodies enable detection of phosphorylated TAM receptors via techniques like Western blotting, immunohistochemistry, or flow cytometry, aiding research into therapeutic targeting. Specificity is often validated using phosphorylation-blocking reagents or kinase-deficient mutants. Understanding TAM receptor activation dynamics provides insights into their dual roles in homeostasis and disease, highlighting their potential as biomarkers or targets for immunotherapy.