Rabbit Polyclonal Adducinα/β(Phospho-Ser726/713) Antibody

The Adducin α/β (Phospho-Ser726/713) antibody is a specialized tool for detecting phosphorylated forms of the Adducin protein family, which plays a critical role in regulating membrane skeletal organization. Adducin consists of α, β, and γ subunits, with α and β subunits forming heterodimers or homodimers that bind to spectrin-actin complexes at cell membrane interfaces. This interaction stabilizes the cortical cytoskeleton, influencing cell shape, motility, and mechanical resilience. Phosphorylation at Ser726 (α subunit) and Ser713 (β subunit) is primarily mediated by protein kinase C (PKC) and other kinases, modulating Adducin’s ability to cap actin filament ends and interact with spectrin. This post-translational modification is implicated in dynamic cellular processes, including signal transduction, ion transport, and stress response. Dysregulation of Adducin phosphorylation has been linked to pathological conditions such as hypertension, diabetic nephropathy, and neurological disorders. The Adducin α/β (Phospho-Ser726/713) antibody is widely used in research to study cytoskeletal dynamics, cellular signaling pathways, and disease mechanisms via techniques like immunoblotting, immunofluorescence, or immunohistochemistry. Its specificity for phosphorylated epitopes makes it valuable for exploring kinase activity, drug responses, and phosphorylation-dependent protein interactions in physiological or disease models. Validation typically includes knockout/knockdown controls to confirm target specificity.