Rabbit Polyclonal SRC-1(Phospho-Thr1179) Antibody

中文名： SRC-1 (Phospho-Thr1179)抗体
别名： NCOA1, BHLHe42, BHLHe74, F-SRC-1, Hin-2 protein, Nuclear receptor coactivator 1, PAX3/NCOA1 fusion protein, KAT13A, Protein Hin-2, Steroid receptor coactivator 1, Steroid receptor coactivator-1, NCoA-1, RIP160, SRC-1, SRC1

货号: IPDX41113

Price： ￥1280

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	咨询技术	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	咨询技术	Human,Mouse,Rat

产品详情

Aliases	NCOA1, BHLHe42, BHLHe74, F-SRC-1, Hin-2 protein, Nuclear receptor coactivator 1, PAX3/NCOA1 fusion protein, KAT13A, Protein Hin-2, Steroid receptor coactivator 1, Steroid receptor coactivator-1, NCoA-1, RIP160, SRC-1, SRC1
Entrez GeneID	8648;
WB Predicted band size	200kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	A synthesized peptide derived from human SRC-1 (Phospho-Thr1179)
Formulation	Purified antibody in PBS with 0.05% sodium azide and 30% glycerol.

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Western blot analysis SRC-1 (Phospho-Thr1179) using Jurkat whole cell lysates

参考文献

以下是关于 SRC-1 (Phospho-Thr1179) 抗体的3篇参考文献示例(注：因文献检索限制，以下为模拟内容，实际需根据真实文献调整)：

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1. **文献名称**: "Phosphorylation of SRC-1 at Thr1179 regulates its coactivator activity in estrogen receptor signaling"

**作者**: Li Y, et al.

**摘要**: 研究揭示了SRC-1在Thr1179位点的磷酸化通过激活MAPK信号通路增强其与雌激素受体(ERα)的相互作用，促进乳腺癌细胞的增殖和迁移，实验通过Phospho-Thr1179抗体验证了磷酸化位点的功能。

2. **文献名称**: "Role of SRC-1 phosphorylation in metabolic reprogramming of adipocytes"

**作者**: Zhang H, et al.

**摘要**: 利用Phospho-Thr1179特异性抗体，证实了AMPK介导的SRC-1 Thr1179磷酸化通过调控PGC-1α的转录活性，影响脂肪细胞线粒体生物合成和能量代谢平衡。

3. **文献名称**: "Dynamic phosphorylation of SRC-1 at Thr1179 mediates circadian clock gene expression"

**作者**: Wang X, et al.

**摘要**: 通过免疫印迹和染色质免疫沉淀(ChIP)实验，发现SRC-1在Thr1179的磷酸化受昼夜节律激酶CK1δ调控，并参与核心生物钟基因(如Bmal1)的转录激活。

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**提示**：建议通过PubMed或Web of Science以关键词“SRC-1 Phospho-Thr1179”或“SRC-1 Thr1179 phosphorylation”检索真实文献，并优先选择近5年、高影响力的期刊研究。

背景信息

The SRC-1 (Phospho-Thr1179) antibody is a specialized tool used to detect the phosphorylated form of Steroid Receptor Coactivator-1 (SRC-1) at threonine residue 1179. SRC-1 is a transcriptional coactivator that enhances the activity of nuclear hormone receptors (e.g., estrogen, progesterone, and androgen receptors) by bridging transcription factors and basal transcriptional machinery. Phosphorylation at Thr1179 is a post-translational modification critical for regulating SRC-1's coactivator function, influencing its interaction with receptors, chromatin remodeling enzymes, and other coregulators. This modification often occurs in response to cellular signaling pathways, such as kinase activation triggered by hormone stimulation or growth factors.

The antibody is widely employed in studies exploring hormone-dependent transcriptional regulation, cancer biology (particularly in breast and prostate cancers), and metabolic disorders. It enables researchers to assess SRC-1 activation status, localization, and its role in signaling cascades via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Understanding SRC-1 phosphorylation dynamics provides insights into mechanisms underlying diseases linked to hormonal dysregulation and offers potential therapeutic targets. The antibody's specificity for the phosphorylated epitope ensures accurate detection of this functionally relevant modification in experimental models.