Rabbit Polyclonal TPPP(Phospho-Ser18) Antibody

The TPPP (Tubulin Polymerization Promoting Protein) Phospho-Ser18 antibody is a specialized tool used to detect the phosphorylated form of TPPP at serine residue 18. TPPP, also known as p25α, is a brain-specific protein implicated in regulating microtubule dynamics by binding to tubulin and stabilizing microtubule networks. Its phosphorylation at Ser18. mediated by kinases like Cdk5 or GSK-3β, modulates its functional interactions with tubulin and other partners. Dysregulation of TPPP phosphorylation is linked to neurodegenerative disorders, particularly α-synucleinopathies such as Parkinson’s disease (PD) and multiple system atrophy (MSA). In these conditions, aberrant phosphorylation may promote pathological aggregation of α-synuclein, contributing to Lewy body or glial cytoplasmic inclusion formation. The Phospho-Ser18 antibody is widely utilized in research to investigate TPPP's role in cellular stress responses, cytoskeletal organization, and disease mechanisms. It is commonly applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess phosphorylation status in cell lines, animal models, or human postmortem tissues. Studies using this antibody have helped elucidate how TPPP phosphorylation influences oligodendroglial dysfunction in MSA or neuronal vulnerability in PD, making it a critical tool for exploring therapeutic targets in neurodegenerative diseases.