Rabbit Polyclonal STF-1(Phospho-Ser203) Antibody

The STF-1 (Phospho-Ser203) antibody is designed to detect the phosphorylated form of the STF-1 protein at serine residue 203. STF-1. also known as Sp5 transcription factor, belongs to the Sp/KLF family of zinc finger proteins involved in regulating gene expression during development and cellular processes. Phosphorylation at Ser203 is a post-translational modification that may modulate STF-1’s transcriptional activity, stability, or interactions with other proteins, though its exact functional role remains under investigation. This antibody is particularly useful in studies focusing on signaling pathways that regulate STF-1 activity, such as Wnt/β-catenin or FGF signaling, which are critical in embryogenesis, stem cell maintenance, and tissue homeostasis. Researchers employ the STF-1 (Phospho-Ser203) antibody in techniques like Western blotting, immunohistochemistry, or immunofluorescence to assess phosphorylation status in response to cellular stimuli or under pathological conditions. Its specificity for the phosphorylated epitope helps differentiate active STF-1 from its non-phosphorylated form, aiding in mechanistic studies of developmental disorders, cancer, or regenerative processes where STF-1 dysregulation may contribute to disease progression. Validation typically includes knockout controls or peptide competition assays to confirm target specificity.