| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HSPH1, Heat shock 105kD beta, Heat shock 110 kDa protein, Heat shock protein 105 kDa, HSP105, HSP110, Heat-shock protein 105 kd, HSP105A, HSP105B, NY-CO-25, KIAA0201, Antigen NY-CO-25, Heat shock 105kD alpha, Heat shock 105kDa protein 1, Heat shock p ... |
| Entrez GeneID | 10808; |
| WB Predicted band size | 100kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human HSP105 (Phospho-Ser809) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于模拟生成的关于HSP105 (Phospho-Ser809)抗体的参考文献示例(实际文献需通过学术数据库核实)：
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1. **文献名称**：*Phosphorylation of HSP105 at Ser809 regulates its chaperone activity and cellular stress response*
**作者**：Yamagishi N, et al.
**摘要**：本研究揭示了HSP105在Ser809位点的磷酸化对其分子伴侣功能的影响，通过Phospho-Ser809特异性抗体验证了热休克或蛋白酶体抑制条件下的磷酸化动态变化，并证明该修饰可增强HSP105对错误折叠蛋白的清除能力。
2. **文献名称**：*A novel role of HSP105 phosphorylation in cancer cell migration and invasion*
**作者**：Tanaka K, et al.
**摘要**：利用Phospho-Ser809抗体，作者发现HSP105在多种癌细胞系中呈现组成型磷酸化。敲除实验表明，Ser809磷酸化通过调控细胞骨架重塑促进肿瘤转移，为靶向HSP105磷酸化的抗癌策略提供依据。
3. **文献名称**：*Validation of a phospho-specific antibody for HSP105 (Ser809) in neurodegenerative disease models*
**作者**：Smith J, et al.
**摘要**：本文验证了HSP105 (Phospho-Ser809)抗体的特异性，通过肽竞争实验和位点突变(Ser809Ala)证明其信号依赖性。在阿尔茨海默病模型中，该抗体检测到磷酸化HSP105在神经元中的异常聚集。
4. **文献名称**：*HSP105 phosphorylation modulates amyloid-β toxicity via regulation of proteostasis*
**作者**：Chen L, et al.
**摘要**：研究使用Phospho-Ser809抗体发现，HSP105磷酸化水平与β淀粉样蛋白诱导的神经毒性负相关。磷酸化HSP105通过与BAG3互作增强自噬通路，缓解错误蛋白积累。
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**注意**：以上为模拟生成的示例，实际文献需通过PubMed、Google Scholar等平台以关键词“HSP105 Phospho-Ser809”或抗体货号(如CST #12345)检索，并参考抗体供应商(如Cell Signaling Technology)的产品说明书引用文献。
The HSP105 (Phospho-Ser809) antibody is a specialized tool for detecting the phosphorylated form of heat shock protein 105 (HSP105) at serine residue 809. HSP105. a member of the HSP70 chaperone family, plays a critical role in cellular stress responses by assisting in protein folding, preventing aggregation of denatured proteins, and promoting cell survival under stress conditions such as heat shock, oxidative stress, or proteotoxic insults. Its activity is tightly regulated by post-translational modifications, including phosphorylation.
Phosphorylation at Ser809 is associated with the activation or functional modulation of HSP105 during stress signaling. This site-specific modification may influence its chaperone activity, interaction with co-factors, or subcellular localization. The HSP105 (Phospho-Ser809) antibody enables researchers to investigate this regulatory mechanism, particularly in studies exploring cellular stress pathways, protein quality control, and diseases linked to proteostasis dysfunction, such as neurodegenerative disorders (e.g., Alzheimer’s, Parkinson’s) or cancer.
Validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, this antibody provides a reliable means to assess HSP105 activation status in response to stressors or therapeutic interventions. Its specificity for the phosphorylated epitope makes it valuable for dissecting signaling cascades involving kinases/phosphatases and evaluating HSP105’s role as a potential biomarker or therapeutic target in stress-related pathologies.
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