| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM128B |
| Uniprot No | Q6NZ67 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-158aa |
| 氨基酸序列 | MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSVPETRGRNKGSAALGGALALAERSSREGSSQRMPRQPSATRLPKGGGPGKSPTRGST |
| 分子量 | 42.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM128B蛋白的参考文献示例(*注：以下文献为虚构示例，实际文献需通过学术数据库检索*)：
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1. **文献名称**: "Expression and functional characterization of recombinant human FAM128B in cancer cell proliferation"
**作者**: Zhang Y, et al.
**摘要**: 本研究通过基因克隆技术在大肠杆菌中重组表达了人源FAM128B蛋白，并验证其在肺癌细胞系中的促增殖作用。结果表明，FAM128B通过调控细胞周期相关蛋白(如Cyclin D1)促进肿瘤生长。
2. **文献名称**: "FAM128B interacts with PI3K/AKT signaling pathway: Insights from structural and biochemical analysis"
**作者**: Smith J, et al.
**摘要**: 通过体外重组表达纯化FAM128B蛋白，结合免疫共沉淀(Co-IP)实验发现其与PI3K/AKT通路关键分子存在相互作用，揭示了其在细胞生存信号转导中的潜在功能。
3. **文献名称**: "Proteomic identification of FAM128B as a novel regulator of DNA damage response"
**作者**: Wang L, et al.
**摘要**: 本研究利用重组FAM128B蛋白进行蛋白质组学筛选，发现其参与DNA损伤修复过程，敲低FAM128B导致细胞对电离辐射敏感性增加，提示其可能在基因组稳定性中发挥作用。
4. **文献名称**: "Crystallographic study of human FAM128B protein: Implications for substrate binding"
**作者**: Tanaka K, et al.
**摘要**: 报道了重组人FAM128B蛋白的晶体结构(分辨率2.5Å)，揭示了其独特的底物结合域，并推测其可能作为酶或适配蛋白参与代谢调控。
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**提示**：实际研究中关于FAM128B的文献可能较少，建议通过PubMed或Google Scholar以“FAM128B protein”“recombinant FAM128B”等关键词检索最新研究，或关注其可能参与的信号通路(如癌症、代谢调控)扩大搜索范围。
Recombinant human FAM128B protein, also known as MYOCOS or BM-020. is a poorly characterized protein encoded by the FAM128B gene on chromosome 6. It belongs to the FAM128 family, which shares a conserved coiled-coil domain, suggesting roles in protein-protein interactions or molecular scaffolding. FAM128B is expressed in multiple tissues, particularly the brain, and localizes to both the nucleus and cytoplasm. While its precise biological function remains unclear, studies suggest it may regulate cell proliferation, differentiation, and survival pathways. Emerging evidence links FAM128B to the MEK/ERK signaling cascade, where it potentially modulates kinase activity through binding partners. Notably, it interacts with NEMO/IKKγ, a regulator of NF-κB signaling, hinting at roles in inflammatory responses or stress signaling. Dysregulation of FAM128B expression has been observed in cancers like glioma, though its pro- or anti-tumorigenic role requires further investigation. Recombinant FAM128B is typically produced in E. coli or mammalian expression systems with tags (e.g., His-tag) for purification. It serves as a critical reagent for functional studies, antibody development, and deciphering its involvement in signaling networks and disease mechanisms. Limited structural or enzymatic data currently exist, highlighting the need for deeper mechanistic exploration.
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