| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR6K2 |
| Uniprot No | Q8NGY2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-324 aa |
| 活性数据 | MESPNRTTIQEFIFSAFPYSWVKSVVCFVPLLFIYAFIVVGNLVIITVVQLNTHLHTPMY TFISALSFLEIWYTTATIPKMLSSLLSERSISFNGCLLQMYFFHSTGICEVCLLTVMAFD HYLAICSPLHYPSIMTPKLCTQLTLSCCVCGFITPLPEIAWISTLPFCGSNHLEHIFCDF LPVLRLACTDTRAIVMIQVVDVIHAVEIITAVMLIFMSYDGIVAVILRIHSAGGRRTAFS TCVSHFIVFSLFFGSVTLMYLRFSATYSLFWDIAIALAFAVLSPFFNPIIYSLRNKEIKE AIKKHIGQAKIFFSVRPGTSSKIF |
| 分子量 | 36.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR6K2蛋白的模拟参考文献示例（仅供格式参考，文献为虚构）：
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1. **文献名称**: "Functional characterization of recombinant human olfactory receptor OR6K2 in heterologous expression systems"
**作者**: Smith A, et al.
**摘要**: 本研究通过HEK293细胞表达重组OR6K2蛋白，利用钙信号检测技术筛选其配体，发现该受体对短链脂肪酸类气味分子具有特异性响应，揭示了其在嗅觉感知中的潜在作用。
2. **文献名称**: "Structural insights into OR6K2 through cryo-EM and molecular dynamics simulations"
**作者**: Lee J, et al.
**摘要**: 通过冷冻电镜技术解析了重组OR6K2蛋白的三维结构，并结合分子动力学模拟阐明了其配体结合口袋的构象变化，为设计靶向嗅觉受体的化合物提供了依据。
3. **文献名称**: "OR6K2 expression profiling and its epigenetic regulation in nasal epithelium"
**作者**: Wang X, et al.
**摘要**: 分析了OR6K2在人类鼻腔组织中的表达模式，发现其转录水平受DNA甲基化调控，并探讨了该受体在非嗅觉组织（如前列腺）中的潜在功能。
4. **文献名称**: "Development of a high-throughput screening assay for OR6K2 agonists/antagonists"
**作者**: García R, et al.
**摘要**: 开发了基于重组OR6K2蛋白的双荧光报告基因检测体系，成功筛选出小分子激动剂，为研究嗅觉受体信号通路及疾病相关应用提供了工具。
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**注意**：以上文献及内容均为模拟示例，实际研究中请根据真实文献引用。如需准确文献，建议通过PubMed、Web of Science等平台检索关键词“OR6K2”或“olfactory receptor OR6K2”。
**Background of Recombinant Human OR6K2 Protein**
The human olfactory receptor OR6K2, encoded by the *OR6K2* gene located on chromosome 19 (19p13.3), belongs to the G protein-coupled receptor (GPCR) superfamily. It is a member of the olfactory receptor (OR) family, which plays a critical role in detecting odorant molecules and mediating signal transduction in olfactory sensory neurons. OR6K2 is characterized by its seven transmembrane domains and ligand-binding specificity, though its exact endogenous ligands remain poorly characterized.
Recombinant OR6K2 protein is produced using genetic engineering techniques, typically expressed in heterologous systems like HEK293 or insect cells to ensure proper post-translational modifications and membrane localization. Its recombinant form allows structural and functional studies, such as elucidating odorant recognition mechanisms, signaling pathways, and potential non-olfactory roles. Emerging research suggests ORs, including OR6K2, might have extranasal functions in tissues like the brain, testes, or gut, linking them to physiological processes beyond smell.
Studying recombinant OR6K2 also aids in exploring genetic variations (e.g., SNPs) associated with odor perception differences or diseases. Despite progress, OR6K2’s precise biological roles and therapeutic relevance remain active areas of investigation, highlighting its significance in both basic and translational research.
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