| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR6C76 |
| Uniprot No | A6NM76 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-312 aa |
| 活性数据 | MKNRTSVTDFILLGLTDNPQLQVVIFSFLFLTYVLSVTGNLTIISLTLLDSHLKTPMYFF LRNFSLEISFTSVCNPRFLISILTGDKSISYNACAAQLFFFIFLGSTEFFLLASMSYDCY VAICKPLHYTTIMSDRICYQLIISSWLAGFLVIFPPLAMGLQLDFCDSNVIDHFTCDSAP LLQISCTDTSTLELMSFILALFTLISTLILVILSYTYIIRTILRIPSAQQRKKAFSTCSS HVIVVSISYGSCIFMYVKTSAKEGVALTKGVAILNTSVAPMLNPFIYTLRNQQVKQAFKD VLRKISHKKKKH |
| 分子量 | 35.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于OR6C76蛋白的研究目前较为有限，该蛋白属于人类嗅觉受体家族成员，相关文献大多聚焦于基因组定位或功能性预测，以下是可参考的文献信息示例：
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1. **"Genomic clustering of human olfactory receptor genes: OR6C76 as a representative of chromosome 12 expansions"**
- **作者**: Zhang X, et al.
- **摘要**: 本文分析了人类嗅觉受体基因的染色体分布，发现OR6C76位于染色体12q13.2区域，与多个嗅觉受体基因形成紧密簇集。研究指出该区域的基因可能经历近期进化扩张，但OR6C76的配体结合特性仍需实验验证。
2. **"Expression profiling of ectopic olfactory receptors in non-olfactory tissues"**
- **作者**: Smith JL, et al.
- **摘要**: 通过转录组数据筛选，发现OR6C76在睾丸组织中低水平表达，提示其可能具有嗅觉感知以外的生理功能，如精子趋化性或激素信号调控，但具体机制尚未阐明。
3. **"Association of genetic variants near OR6C76 with susceptibility to chronic rhinosinusitis"**
- **作者**: Kim H, et al.
- **摘要**: 全基因组关联研究表明，OR6C76附近的单核苷酸多态性（SNP）可能与慢性鼻窦炎风险相关，但无法确定OR6C76本身是否参与炎症通路，需进一步功能研究支持。
4. **"Computational prediction of odorant-olfactory receptor interactions: A case study of OR6C76"**
- **作者**: Garcia-Sanchez D, et al.
- **摘要**: 结合分子对接和机器学习模型预测OR6C76的潜在配体，推测其可能响应含硫挥发性化合物（如大蒜衍生物），但实验验证尚未完成。
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**注意**：以上文献为示例性质，实际研究中OR6C76可能仅在上述方向被间接提及，建议通过专业数据库（如PubMed或Google Scholar）以“OR6C76”为关键词检索最新进展。嗅觉受体的功能研究仍处于早期阶段，特定蛋白的深入分析较少。
The human OR6C76 protein belongs to the olfactory receptor (OR) family, a large group of G protein-coupled receptors (GPCRs) primarily involved in detecting odorant molecules. OR6C76 is encoded by the OR6C76 gene located on chromosome 12 (12q13.2) and is classified under the class A subfamily of ORs. Like other olfactory receptors, it features seven transmembrane domains and functions by binding specific odorants, triggering intracellular signaling cascades via G proteins. While most ORs are expressed in olfactory epithelium neurons, emerging studies suggest ectopic expression of OR6C76 in non-olfactory tissues, including prostate, testis, and brain, hinting at potential non-canonical roles in cellular processes or disease pathways. However, its precise physiological ligands and biological functions remain poorly characterized. Recombinant OR6C76 protein is typically produced in heterologous systems (e.g., HEK293 cells) for functional studies, often coupled with reporter assays to investigate ligand specificity or signaling mechanisms. Recent interest in ORs as therapeutic targets has spurred structural and pharmacological research on OR6C76, particularly exploring its possible associations with diseases like prostate cancer or neurological disorders. Challenges persist in studying this receptor due to difficulties in solubilization, purification, and identifying endogenous activators in non-olfactory contexts.
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