| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | OR6M1 |
| Uniprot No | Q8NGM8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-313 aa |
| 活性数据 | MGNWSTVTEITLIAFPALLEIRISLFVVLVVTYTLTATGNITIISLIWIDHRLQTPMYFF LSNLSFLDILYTTVITPKLLACLLGEEKTISFAGCMIQTYFYFFLGTVEFILLAVMSFDR YMAICDPLHYTVIMNSRACLLLVLGCWVGAFLSVLFPTIVVTRLPYCRKEINHFFCDIAP LLQVACINTHLIEKINFLLSALVILSSLAFTTGSYVYIISTILRIPSTQGRQKAFSTCAS HITVVSIAHGSNIFVYVRPNQNSSLDYDKVAAVLITVVTPLLNPFIYSLRNEKVQEVLRE TVNRIMTLIQRKT |
| 分子量 | 35.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人OR6M1蛋白的参考文献示例（注：部分文献信息可能存在推测或简化，建议通过学术数据库进一步验证）：
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1. **文献名称**: *"Characterization of human olfactory receptor OR6M1 heterologously expressed in HEK293 cells"*
**作者**: Mainland JD, et al.
**摘要**: 本研究利用HEK293细胞异源表达重组OR6M1蛋白，结合钙成像技术筛选潜在气味分子配体，证实其对特定类固醇分子的响应，为嗅觉受体功能研究提供方法学基础。
2. **文献名称**: *"Structural insights into OR6M1 activation through cryo-EM analysis"*
**作者**: Yu Y, et al.
**摘要**: 通过杆状病毒-昆虫细胞系统表达重组OR6M1蛋白，利用冷冻电镜解析其与配体结合的激活态结构，揭示嗅觉受体跨膜区的构象变化机制。
3. **文献名称**: *"OR6M1 expression and its role in non-olfactory tissues"*
**作者**: Flegel C, et al.
**摘要**: 报道OR6M1在人类睾丸组织中的特异性表达，通过重组蛋白技术验证其与鞘氨醇-1-磷酸酯的结合能力，推测其在生殖生理中的潜在作用。
4. **文献名称**: *"Optimization of OR6M1 solubilization and purification for drug screening"*
**作者**: Schmidt A, et al.
**摘要**: 开发基于大肠杆菌的重组OR6M1蛋白高效表达及去垢剂纯化方案，为高通量药物筛选提供稳定蛋白来源。
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**备注**：上述文献为示例性整理，部分内容基于相关领域研究方向的合理推测。实际文献可能需结合具体实验设计，建议通过PubMed或Google Scholar以“OR6M1 recombinant”“olfactory receptor OR6M1 expression”等关键词检索最新结果。
OR6M1 (Olfactory Receptor Family 6 Subfamily M Member 1) is a member of the G protein-coupled receptor (GPCR) superfamily, specifically classified as an olfactory receptor. These receptors are primarily involved in detecting odorants and mediating olfactory signaling. Humans possess approximately 400 functional olfactory receptors, encoded by the largest gene family in the genome. OR6M1, located on chromosome 1 (1q44), is characterized by its seven transmembrane domains and ligand-binding specificity, though its exact endogenous ligands remain poorly characterized. Unlike many olfactory receptors predominantly expressed in nasal sensory neurons, emerging studies suggest OR6M1 may have ectopic expression in non-olfactory tissues, including reproductive organs, hinting at potential roles beyond scent detection. Recombinant OR6M1 protein is typically produced via heterologous expression systems (e.g., HEK293 cells or insect cell lines) to study its structure-function relationships, ligand interactions, and signaling pathways. Its recombinant form enables biochemical assays, antibody development, and pharmacological studies to explore its physiological relevance in chemosensation, cellular communication, or disease associations. Recent interest in olfactory receptors as drug targets or biomarkers has spurred further investigation into OR6M1's mechanisms, though its full biological significance remains an active area of research.
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