| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PCDHB13 |
| Uniprot No | Q9Y5F0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-798 aa |
| 活性数据 | MEASGKLICRQRQVLFSFLLLGLSLAGAAEPRSYSVVEETEGSSFVTNLAKDLGLEQREFSRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQAELQVIDINDHSPVFLDKQMLVKVSESSPPGTTFPLKNAEDLDVGQNNIENYIISPNSYFRVLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFYRVQISEDSPVGFLVVKVSATDVDTGVNGEISYSLFQASEEIGKTFKINPLTGEIELKKQLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPENAPETVVALFSVSDLDSGENGKISCSIQEDLPFLLKSAENFYTLLTERPLDRESRAEYNITITVTDLGTPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSGTNAQVTYSLLPPQDPHLPLTSLVSINADNGHLFALRSLDYEALQGFQFRVGASDHGSPALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPTQAQADLLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCLVPEGPLPGHLVDMSGTRTLSQSYQYEVCLAGGSGTNEFKFLKPIIPNFPPQCPGKEIQGNSTFPNNFGFNIQ |
| 分子量 | 114 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为虚构的示例文献，仅供参考。实际文献需通过学术数据库检索：
1. **《重组人PCDHB13蛋白在细胞黏附中的功能研究》**
- 作者：Smith A, et al.
- 摘要：研究通过重组表达人PCDHB13蛋白，发现其通过调控钙离子依赖性细胞黏附通路抑制肿瘤细胞迁移，并揭示了其胞外结构域的关键作用。
2. **《PCDHB13在胃癌中的异常表达及其临床意义》**
- 作者：Zhang L, et al.
- 摘要：本文利用重组PCDHB13蛋白制备抗体，发现其在胃癌组织中低表达，与患者预后不良相关，提示其可能作为潜在的肿瘤抑制因子。
3. **《原钙粘蛋白PCDHB13胞外结构域的结构解析》**
- 作者：Chen H, et al.
- 摘要：通过X射线晶体学解析重组PCDHB13胞外结构域的三维结构，揭示了其独特的钙结合位点，为研究其分子互作机制提供结构基础。
4. **《PCDHB13在神经元突触发育中的功能研究》**
- 作者：Lee J, et al.
- 摘要：利用重组PCDHB13蛋白进行体外神经元培养实验，发现其促进突触形成，并参与轴突导向信号通路的调控。
**备注**：上述内容为模拟文献，实际研究中PCDHB13相关论文较少，建议通过PubMed、Web of Science等平台以“PCDHB13”或“protocadherin beta 13”为关键词查找最新文献。
The human protocadherin beta-13 (PCDHB13) protein belongs to the protocadherin β subfamily, a group of transmembrane cell adhesion molecules within the larger cadherin superfamily. Protocadherins are primarily expressed in the nervous system and play critical roles in neuronal development, including axon guidance, synaptic specificity, and the establishment of neural circuit connectivity. PCDHB13. encoded by the *PCDHB13* gene located on chromosome 5q31. features a typical protocadherin structure: an extracellular domain with multiple cadherin-like repeats that mediate calcium-dependent homophilic interactions, a single-pass transmembrane region, and a short cytoplasmic tail lacking conserved signaling motifs. While the exact functional role of PCDHB13 remains understudied, it is hypothesized to contribute to cell-cell recognition and tissue patterning, particularly during brain development.
Emerging evidence suggests that PCDHB13 may be dysregulated in certain cancers, potentially influencing tumor invasiveness or metastasis, though mechanistic insights are limited. Recombinant PCDHB13 protein, produced via heterologous expression systems (e.g., mammalian or bacterial cells), enables in vitro studies to characterize its binding properties, structural dynamics, and interactions with signaling partners. Its application spans antibody development, functional assays, and exploration of pathogenic variants linked to neurodevelopmental disorders. Further research is needed to elucidate its precise physiological and pathological roles, offering opportunities to explore its therapeutic or diagnostic potential.
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