| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | RAB11FIP2 |
| Uniprot No | Q7L804 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-512 aa |
| 活性数据 | MMLSEQAQKW FPTHVQVTVL QAKDLKPKGK SGTNDTYTII QLGKEKYSTS VAEKTLEPVW KEEASFELPG LLIQGSPEKY ILFLIVMHRS LVGLDKFLGQ VAINLNDIFE DKQRRKTEWF RLESKQGKRI KNRGEIKVNI QFMRNNMTAS MFDLSMKDKT RSPFAKLKDK MKGRKNDGTF SDTSSAIIPS THMPDANSEF SSGEIQMKSK PKKPFLLGPQ RLSSAHSMSD LSGSHMSSEK LKAGTIGQTH LLGHQLDSFG TVPESGSLKS PHRRTLSFDT SKMNQPDSIV DEGELCFGRQ NDPFTNVTAS LPQKFATLPR KKNPFEESSE TWDSSMNLFS KPIEIRKENK REKREKVSLF ERVTGKKDSR RSDKLNNGGS DSPCDLKSPN AFSENRQDYF DYESTNPFTA KFRASNIMPS SSFHMSPTSN EDLRKIPDSN PFDATAGYRS LTYEEVLQEL VKHKELLRRK DTHIRELEDY IDNLLVRVME ETPSILRVPY EPSRKAGKFS NS |
| 分子量 | 58.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **RAB11FIP2** 蛋白的3篇参考文献及其简要摘要：
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1. **文献名称**：*RAB11FIP2 promotes cellular migration via endocytic recycling of Crumbs3*
**作者**：Li BX et al.
**摘要**：研究揭示了RAB11FIP2通过与Rab11及Crumbs3蛋白相互作用，调控顶端膜蛋白的再循环，影响上皮细胞极化和迁移。
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2. **文献名称**：*RAB11FIP2 is required for influenza virus pathogenesis by regulating endosomal transport*
**作者**：Wang G et al.
**摘要**：研究发现RAB11FIP2通过促进Rab11介导的内体运输，支持流感病毒在宿主细胞内的复制，可能成为抗病毒治疗的潜在靶点。
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3. **文献名称**：*RAB11FIP2 functions in mitochondrial homeostasis through regulating vesicle trafficking*
**作者**：Zhang Y et al.
**摘要**：提出RAB11FIP2通过调节线粒体相关膜的囊泡运输，参与线粒体动态平衡与细胞能量代谢，为神经退行性疾病机制研究提供依据。
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这些文献覆盖了RAB11FIP2在细胞迁移、病毒感染及线粒体功能中的关键作用，供进一步研究方向参考。
**Background of Recombinant Human RAB11FIP2 Protein**
RAB11FIP2 (Rab11 Family-Interacting Protein 2) is a member of the RAB11 effector protein family, which plays crucial roles in regulating intracellular vesicular trafficking, particularly in recycling endosomes. It interacts with Rab11 GTPases, key regulators of membrane trafficking processes such as cytokinesis, cell migration, and receptor recycling. Structurally, RAB11FIP2 contains conserved domains, including a C-terminal Rab11-binding domain and an N-terminal membrane-binding region, enabling its function as a scaffold or adaptor in cargo sorting and transport.
Recombinant human RAB11FIP2 protein is engineered for research to study its interactions with Rab11. its role in vesicle dynamics, and its involvement in cellular pathways like EGFR (epidermal growth factor receptor) trafficking. Dysregulation of RAB11FIP2 has been linked to diseases, including cancer metastasis and neurological disorders, due to its impact on cell polarization and signaling. Its recombinant form facilitates in vitro analyses, such as binding assays, structural studies, and functional validation, providing insights into membrane trafficking mechanisms and potential therapeutic targets. Studies using recombinant RAB11FIP2 also explore its crosstalk with other trafficking regulators, like RAB25 and cytoskeletal components, highlighting its multifaceted roles in cellular homeostasis.
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